Respiratory viruses in neonates hospitalized with acute lower respiratory tract infections

Cho, Hye‐Kyung; Shim, So-Yeon; Son, Dong Woo; Sun, Yong Han; Tchah, Hann; Jeon, In-sang

doi:10.1111/j.1442-200x.2012.03727.x

Cited by 29 publications

(50 citation statements)

References 33 publications

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“…Infants <31 days were not enrolled; therefore, we do not have data on the epidemiology of viral pathogens in this age group and it is possible that we have underestimated the incidence of hospitalized ARIs in children aged 1 month <5 years. However, published estimates on neonates aged <1 month demonstrated proportional viral etiologies similar to patients aged 31 days to <1 year in our study . Additionally, although every effort was made to include all hospitalized infectious respiratory cases at our study sites, the inclusion criteria were biased toward certain symptomologies.…”

Section: Discussionmentioning

confidence: 81%

Incidence and etiology of hospitalized acute respiratory infections in the Egyptian Delta

Rowlinson

Dueger

Mansour

et al. 2016

Influenza Resp Viruses

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IntroductionAcute Respiratory Infections (ARI) are responsible for nearly two million childhood deaths worldwide. A limited number of studies have been published on the epidemiology of viral respiratory pathogens in Egypt.MethodsA total of 6113 hospitalized patients >1 month of age with suspected ARI were enrolled between June 23, 2009 and December 31, 2013. Naso‐ and oropharyngeal specimens were collected and tested for influenza A and B, respiratory syncytial virus, human metapneumovirus, adenovirus, and parainfluenza viruses 1–3. Blood specimens from children 1–11 months were cultured and bacterial growth was identified by polymerase chain reaction. Results from a healthcare utilization survey on the proportion of persons seeking care for ARI was used to calculate adjusted ARI incidence rates in the surveillance population.ResultsThe proportion of patients with a viral pathogen detected decreased with age from 67% in patients age 1–11 months to 19% in patients ≥65 years of age. Influenza was the dominant viral pathogen detected in patients ≥1 year of age (13.9%). The highest incidence rates for hospitalized ARI were observed in children 1–11 months (1757.9–5537.5/100 000 population) and RSV was the most commonly detected pathogen in this age group.ConclusionIn this study population, influenza is the largest viral contributor to hospitalized ARIs and children 1–11 months of age experience a high rate of ARI hospitalizations. This study highlights a need for surveillance of additional viral pathogens and alternative detection methods for bacterial pathogens, which may reveal a substantial proportion of as yet unidentified etiologies in adults.

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Section: Discussionmentioning

confidence: 81%

Incidence and etiology of hospitalized acute respiratory infections in the Egyptian Delta

Rowlinson

Dueger

Mansour

et al. 2016

Influenza Resp Viruses

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“…Thirty‐seven studies from 24 countries published between 2002 and 2014, with suitable case fatality data among children <5 years of age with community‐acquired, medically attended, confirmed RSV‐ARI were included in the mortality analysis. The case fatality estimates (reported per 1,000 children) were stratified according to age and region (Table ).…”

Section: Resultsmentioning

confidence: 99%

Respiratory syncytial virus hospitalization and mortality: Systematic review and meta‐analysis

Stein

Bont

Zar

et al. 2016

Pediatric Pulmonology

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SummaryBackground: Respiratory syncytial virus (RSV) is a major public health burden worldwide. We aimed to review the current literature on the incidence and mortality of severe RSV in children globally. Methods: Systematic literature review and meta‐analysis of published data from 2000 onwards, reporting on burden of acute respiratory infection (ARI) due to RSV in children. Main outcomes were hospitalization for severe RSV‐ARI and death. Results: Five thousand two hundred and seventy‐four references were identified. Fifty‐five studies were included from 32 countries. The global RSV‐ARI hospitalization estimates, reported per 1,000 children per year (95% Credible Interval (CrI), were 4.37 (2.98, 6.42) among children <5 years, 19.19 (15.04, 24.48) among children <1 year, 20.01 (9.65, 41.31) among children <6 months and 63.85 (37.52, 109.70) among premature children <1 year. The RSV‐ARI global case‐fatality estimates, reported per 1,000 children, (95% Crl) were 6.21 (2.64, 13.73) among children <5 years, 6.60 (1.85, 16.93) for children <1 year, and 1.04 (0.17, 12.06) among preterm children <1 year. Conclusions: A substantial proportion of RSV‐associated morbidity occurs in the first year of life, especially in children born prematurely. These data affirm the importance of RSV disease in the causation of hospitalization and as a significant contributor to pediatric mortality and further demonstrate gestational age as a critical determinant of disease severity. An important limitation of case‐fatality ratios is the absence of individual patient characteristics of non‐surviving patients. Moreover, case‐fatality ratios cannot be translated to population‐based mortality. Pediatr Pulmonol. 2017;52:556–569. © 2016 The Authors. Pediatric Pulmonology. Published by Wiley Periodicals, Inc.

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“…Tablo II: Viral ASYE nedeniyle yatırılan hastaların demografik özellikleri. RSV ilişkili enfeksiyonların daha ağır klinik seyire neden olduğu bildirilmektedir (4,9,12,13). Viral etken olarak RSV saptanan yenidoğanların, RSV dışı virüs saptananlara göre daha ağır solunum sıkıntısı bulgularının olduğu, oksijen gereksinimi nedeniyle hastaneye yatış oranlarının daha fazla olduğu bildirilmiştir (14).…”

Section: Introductionunclassified

“…Viral etken olarak RSV saptanan yenidoğanların, RSV dışı virüs saptananlara göre daha ağır solunum sıkıntısı bulgularının olduğu, oksijen gereksinimi nedeniyle hastaneye yatış oranlarının daha fazla olduğu bildirilmiştir (14). Yine bir başka çalışmada RSV nedeniyle hastaneye yatırılan yenidoğanların klinik bulgularının daha ağır, anormal akciğer grafisi bulgularının daha fazla ve daha uzun hastanede yatış süresi olduğu bildirilmiştir (9). Ayrıca bazı çalışmalarda ikili viral etken birlikteliği %8.8-40 oranında ve etken olarak çift virüsün saptandığı enfeksiyonların daha şiddetli seyrettiği bildirilmiştir (9,15,16 Bir ayın altında sağlıklı yenidoğanlarda RSV ilişkili ASYE ile ilgili çok az çalışma mevcuttur (2,19).…”

Section: Introductionunclassified

The Epidemiological and Clinical Features of Neonates Hospitalized with Lower Respiratory Tract Viral Infections

Okulu¹,

Akduman²,

Tunç³

et al. 2017

Turkish J Pediatr Dis

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ÖZAmaç: Çalışmada, yenidoğan yoğun bakım ünitesine alt solunum yolu enfeksiyonu nedeniyle yatırılan ve viral etken tespit edilen yenidoğanların epidemiyolojik ve klinik özelliklerinin araştırılması amaçlanmıştır. Gereç ve Yöntemler:1 Ocak 2014-31 Aralık 2015 arasında alt solunum yolu enfeksiyonu nedeniyle yatırılan yenidoğanların özellikleri ve nazofarenjiyal aspirat örneklerinde PCR yöntemiyle saptanan viral etkenler araştırıldı. Konjenital kalp hastalığı, konjenital solunum yolları anomalisi, immün yetmezliği olan hastalar ile nozokomiyal kaynaklı viral enfeksiyonlar çalışmaya dahil edilmedi. Bulgular: Çalışma döneminde yatan toplam 1768 hastanın 81'i (%4.6) akut alt solunum yolu enfeksiyonu tanısı aldı, 56'sında (%69.1) viral etken izole edildi. En sık izole edilen etken respiratuvar sinsityal virüs (RSV)'di (%80.4, n=45), dört hastada (%7.1) RSV ile birlikte ikinci virüs izole edildi, 7 hastada (%12.5) RSV dışı virüs saptandı. Yatışlar en sık Şubat ve Ocak aylarında idi. Viral etken olarak RSV saptanan hasta grubunun hastaneye yatış gün ortancası (21 gün), RSV dışı virüs saptanan hasta grubuna (41 gün) göre anlamlı düşüktü (p=0.011). RSV ve RSV dışı virüslerin etken olduğu hasta gruplarında, hastaneye başvuru bulguları, başvurudaki laboratuvar bulguları, uygulanan solunum desteği açısından fark saptanmadı. Hastanede yatış süresi ortalaması tüm hasta grubunda 7.1±3.6 gün olup, RSV ve RSV koenfeksiyon grubunda, RSV dışı virüs saptanan gruba göre anlamlı olarak uzun idi (7.3±3.8 ve 4.8±3.1 gün, p=0.03). Kaybedilen hasta olmadı.Sonuç: Yoğun bakım ünitesine alt solunum yolu enfeksiyonu nedeniyle yatırılan yenidoğanlarda en sık izole edilen etken RSV'dir. RSV enfeksiyonuna bağlı hastane yatışları en sık Ocak-Şubat aylarında olup, daha erken postnatal günlerde gerçekleşmektedir. Yatış gerektiren yenidoğanlarda epidemiyolojik ve klinik faktörlerin bilinmesi engelleyici yaklaşımların geliştirilmesine olanak sağlayacaktır.Anahtar Sözcükler: Alt solunum yolu enfeksiyonu, Respiratuvar sinsityal virüs, Viral, Yenidoğan ABSTRACT Objective: We aimed to define the clinical and epidemiological features of neonates hospitalized in the neonatal care unit with virus-related to lower respiratory tract infections in this study. Material and Methods:The neonates who were hospitalized with lower respiratory tract infection between January 2014 and December 2015 were evaluated for clinical features and the viruses were identified on multiplex reverse transcription polymerase chain reaction using nasal swab samples. Neonates with congenital heart disease, malformation of the respiratory tract, immune deficiency and nosocomial virus infection were excluded.Results: Eighty-one (4.6%) of 1768 neonates were admitted to NICU with lower respiratory tract infection during the study period. In 56 of 81 patients, a virus was identified from the nasal swab sample. Respiratory syncytial virus (RSV) was the most common etiology (80.4%, n=45), four patients had RSV co-infection (7.1%), and seven patients had a virus other than RSV (12.5%). Infant...

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Respiratory viruses in neonates hospitalized with acute lower respiratory tract infections

Abstract: RSV was the most common viral etiology in neonates without underlying diseases who were hospitalized with ALRI. The disease severity of RSV infection was worse than that of other detected viral infections. Strict prevention strategies should be considered in overcrowded situations.

Cited by 29 publications

References 33 publications

Incidence and etiology of hospitalized acute respiratory infections in the Egyptian Delta

Incidence and etiology of hospitalized acute respiratory infections in the Egyptian Delta

Respiratory syncytial virus hospitalization and mortality: Systematic review and meta‐analysis

The Epidemiological and Clinical Features of Neonates Hospitalized with Lower Respiratory Tract Viral Infections

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