Responding to signals of mental and behavioral health risk in pragmatic clinical trials: Ethical obligations in a healthcare ecosystem

“Click and mortar” opportunities for digitization and consumerism in trials

“…How can the privacy and security of highly sensitive, digital health information be guaranteed? How will the remote study team respond to signals of harm [ 42 ], and what oversight is required from the research organization and/or sponsor? How can this intervention be delivered equitably?…”