A communication board game (My Wonderful Life Board Game) was designed for patients with chronic or advanced illness to engage in self-reflection and discovery, emotional expression, and discussion wishes and concerns in end of life. The game's use is illustrated through case studies. My Wonderful Life (MWL) board game was administered with five patients diagnosed with advanced cancer in Shenzhen, China. With each patient, the MWL game was conducted for three sessions, each session lasting 60-90 minutes. Qualitative process study with the participants revealed the beneficial components of the MWL game reported by the patients. They include: a) leaving a legacy; b) preparing family and self for end of life; c) appreciating self and achievements; d) sharing of feelings, appreciation, and concerns; and e) distractions from pain and negative thoughts. The MWL game facilitated patients entering into therapy and enhanced therapeutic outcomes. With the aid of the game, exploration and revelation were both speeded up and deepened. The game also offered a sense of closure that could enhance the psychological well-being of individuals facing impending death. In conclusion, the MWL game is a useful tool for psychological work with patients with advanced illness.