Response and recovery of gibel carp from subchronic oral administration of aflatoxin B1

Huang, Ying; Han, Dong; Zhu, Xiaoming; Yang, Yunxia; Jin, Junyan; Chen, Yifeng; Xie, Shouqi

doi:10.1016/j.aquaculture.2011.06.024

Cited by 58 publications

(56 citation statements)

References 51 publications

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“…However, in the present study, no fish died after 24 weeks of AFB 1 exposure, nor did we observe any external or behavioral changes such as regurgitation of feed, lethargy, loss of equilibrium and rapid opercular movement. Similar results have been reported in previous researches with channel catfish (Jantrarotai and Lovell, 1990) and gibel carp (Huang et al, 2011). The differences among fish species concerning their sensitivity for AFB 1 were mentioned by Ngethe et al (1993) who concluded that there are species differences in the metabolism of AFB 1 in the liver and affinity of AFB 1 -derived metabolites to hepatic macromolecules.…”

Section: Afb 1 Levels In the Experimental Dietssupporting

confidence: 78%

“…Deng et al (2010) reported 13.3 μg kg −1 of AFB 1 in soybean meal, 1.6 μg kg −1 in fish meal and 62.6 μg kg −1 in peanut meal, respectively and the contaminated ingredients make the control diet with a high concentration of AFB 1 up to 19 μg kg − 1 . Several other publications also reported that AFB 1 was detected in control diet even without any supplementation of AFB 1 (Boonyaratpalin et al, 2001;Han et al, 2009;Huang et al, 2011). -Banna et al (1992) reported that fish fed with a 0.2 mg AFB kg −1 diet had 16.7% mortality.…”

Section: Afb 1 Levels In the Experimental Dietsmentioning

confidence: 97%

“…Previous studies in our laboratory demonstrated that chronic ) for 12 weeks did not affect growth rate, food conversion efficiency and liver function of juvenile gibel carp (Huang et al, 2011). In fact, the toxic effect of AFB 1 is not only dependent on the AFB 1 dose in the feed, but also depends on the duration of toxin exposure, as well as the age of animal (Deng et al, 2010;Eaton and Groopman, 1994).…”

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confidence: 99%

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Effect of dietary aflatoxin B 1 on growth, fecundity and tissue accumulation in gibel carp during the stage of gonad development

et al. 2014

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Section: Afb 1 Levels In the Experimental Dietssupporting

confidence: 78%

Section: Afb 1 Levels In the Experimental Dietsmentioning

confidence: 97%

mentioning

confidence: 99%

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Effect of dietary aflatoxin B 1 on growth, fecundity and tissue accumulation in gibel carp during the stage of gonad development

et al. 2014

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“…Contrary to the current result, Alpsoy et al [30] found that in human lymphocytes, AFB1 significantly decreased the activities of SOD. While, Huang et al [32] showed that, the activities of SOD were not significantly different in the AFB1 exposed groups compared to the controls. These discrepancies might be due to difference in the concentrations and the uptake route of AFB1.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Role of Aflatoxin B1 on the Liver of Wheat Milling Workers

Saad-Hussein¹,

Abdalla²,

Shousha³

et al. 2014

Open Access Maced J Med Sci

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Aim: The study aimed to estimate oxidative role of aflatoxin B1 (AFB1) on the liver in wheat milling workers. Materials and Methods:Case-control study was conducted to compare between the levels of AFB1/albumin (AFB1/alb), liver enzymes (ALT, AST, GGT, and ALP), P53, MDA, GST, SOD, zinc and vitamin C in 35 wheat milling workers and 40 control subjects.Results: Statistical analysis revealed that ALT, AST, GGT, ALP, P53, MDA, GST and SOD in workers were significantly elevated compared to their controls. In the milling workers, there were significant correlations between MDA levels and the levels of AST, GGT, and P53, while, P53 was inversely correlated with GST and SOD activities. There were significant correlations between Zn levels and GGT, GST and SOD activities, between vitamin C and GST activities, and vitamin C inversely correlated with MDA. Conclusion:The present study concluded that the oxidative stress of AFB1 elevated the MDA and the liver enzymes in wheat milling workers. GST has a crucial role in the detoxification of aflatoxin and SOD as a scavenger antioxidant increased in the workers to overcome the oxidative toxic effects of AFB1 on the liver of the workers, and roles of Zn and vitamin C were significant in activation of these processes.

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“…AFB1 in muscles in all groups were all below the safety limit of 0.005 mg/kg wet weight. These results show that AFB1 exposure to about 2 mg/kg diet have no apparent effect on the growth and liver function of gibel carp, but it would harm fertility of fish (Huang et al, 2011). Raghavan (2011) studied the toxicity of aflatoxin B1 in juvenile hybrid sturgeon Acipenserruthenus baeri.…”

Section: Afb1 Residues In Fishmentioning

confidence: 99%

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Hussain¹

2018

Turk. J. Fish. Aquat. Sci.

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Aflatoxins are among all known mycotoxins, the most widespread source of contamination of food and feed throughout the world. In aquaculture and aqua-feed formulations the increased use of plant based materials has intensified the risks of aflatoxicosis in farmed fish because of the high load of aflatoxin by the vegetable sources. The aflatoxins production by toxic fungal strains can take place in the field directly, during different processing stages like insiling, aqua feed formulation, preparation and due to improper feed storage. However, the thermal treatments can only destroy the fungus but have no effect on the heat-resistant mycotoxins present in mycelium and spores of the mold. So, the aflatoxin accumulation in fish meal and fish feed represents a great threat for the aqua-cultured species and ultimately for the consumer's health and safety. Consequently, the issue of aflatoxin contamination in fish and aquaculture industry has intensified. This review focused on the deleterious effects of aflatoxins in fish and aquaculture and the possible remedy by the use of adsorbents.

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Response and recovery of gibel carp from subchronic oral administration of aflatoxin B1

Cited by 58 publications

References 51 publications

Effect of dietary aflatoxin B 1 on growth, fecundity and tissue accumulation in gibel carp during the stage of gonad development

Effect of dietary aflatoxin B 1 on growth, fecundity and tissue accumulation in gibel carp during the stage of gonad development

Oxidative Role of Aflatoxin B1 on the Liver of Wheat Milling Workers

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