Response by the corpuscles of Stannius to hypotensive stimuli in three divergent ray-finned fishes (Amia calva, Anguilla rostrata, and Catastomus commersoni): cardiovascular and morphological changes

Abstract

In accordance with their vital role in cardiovascular physiology () corpuscles of Stannius (CS) from two teleosts and an holostean species showed marked and consistent degranulation and exocytotic responses to hypotensive stimuli. In eels (Anguilla rostrata LeSueur) acute blood withdrawal (hypovolemic hypotension) was followed by a prompt decrease in cardiac output (CO) and dorsal aortic pressure (P(DA)), a compensatory tachycardic response and an increase in systemic vascular resistance (R(SYS)). Isovolemic hypotension induced by papaverine i.v., led to a similar, but more prolonged, decrease in P(DA) but the heart rate (HR) continued to accelerate, thereby counterbalancing the severe and persistent decrease in R(SYS). Both hypovolemic and isovolemic hypotension were followed by a significant depletion of cytoplasmic granules from eel CS even though plasma concentrations of Ca, Mg, Na(+), and K(+) were normal. In an ancient holostean fish, the bowfin, Amia calva and a generalized teleost fish, Catastomus commersoni, the number of cytoplasmic granules decreased by 39% and 54%, respectively, 120 min after the acute withdrawal of 8 ml kg bw(-1) of blood. These findings suggest that a primary role of the CS is to release cytoplasmic granules containing renin or isorenin into the blood circulation, in response to hypotension and/or hypovolemia.

The zebrafish pronephros: A model to study nephron segmentation

“…41 Studies in eels have linked the Corpuscle of Stannius to changes in blood pressure, raising the speculative possibility that there is an evolutionary tie between it and the macula densa. 42 …”

Loss of TIMP3 Enhances Interstitial Nephritis and Fibrosis

“…11 In this study, we examined the role of TIMP3 in agedependent kidney disease as well as in response to an experimental model of renal injury. We used a well established model of tubulointerstitial injury, unilateral ureteral obstruction (UUO), [12][13][14] and characterized the mechanism of renal injury progression in mice lacking TIMP3 (TIMP3 Ϫ/Ϫ ) compared with wild-type (WT) control mice. Here we demonstrate that early activation of the TNF␣ signaling pathway in the absence of TIMP3 is accompanied by enhanced MMP activation, apoptosis, and neutrophil infiltration, which collectively contribute to the accelerated and severe tubulointerstitial injury.…”

Transcriptomic responses of corpuscle of Stannius gland of Japanese eels (Anguilla japonica) to Changes in Water Salinity

“…In STX fishes, a decrease of dorsal aortic blood pressure was reported18. An injection of CS extracts increased blood pressure of fish54.…”

“…Surgical removal of the CS glands (stannioectomized, STX) from fishes causes plasma hypercalcemia6 as well as a reduction of plasma Na + and Cl - levels78, and a decrease in dorsal aortic blood pressure9. Intriguingly, STX fishes that were maintained in low-calcium water did not suffer from the rise of serum Ca 2+ levels.…”

“…One of the major active principles in CS gland extracts, a hypocalcemic hormone named stanniocalcin-1 (STC-1), was identified in 1980s14151617. However, the characteristic and significance of other substance(s) with ion-osmoregulatory and pressor functions remain unknown18192021.…”