Response: Heart Rate and Pulse Wave Velocity

Lantelme, Pierre; Mestre, Christine; Lièvre, Michel; Gressard, A; Milon, H

doi:10.1161/01.hyp.0000038735.23464.7d

Cited by 14 publications

(18 citation statements)

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“…However, a limited number of studies have investigated the acute effects of heart rate changes on arterial stiffness in humans (Tan et al 2018). A few studies have reported that acute increases in heart rate lead to a significant increase in PWV (Liang et al 1999, Lantelme et al 2002, Haesler et al 2004, Millasseau et al 2005, Tan et al 2016. The most physiologically logical explanation for the effect of heart rate changes on arterial stiffness, as assessed by PWV, was the frequency-dependent viscoelasticity of the arterial wall (Tan et al 2018), whereas the mediating role of blood pressure (BP) in this relationship (PWV-heart rate) is unknown.…”

Section: Introductionmentioning

confidence: 99%

The influence of resting heart rate on pulse wave velocity measurement is mediated by blood pressure and depends on aortic stiffness levels: insights from the Corinthia study

et al. 2019

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Objective: Increased resting heart rate as well as increased arterial stiffness are both independent predictors of cardiovascular events and mortality. Results of previous studies have failed to converge concerning the association between heart rate and arterial stiffness, regardless of other potential confounders, such as age, gender and particularly blood pressure (BP). We aimed to investigate: (a) the degree of association (if any) between resting heart rate and carotid-to-femoral pulse wave velocity (PWV), the gold standard index of arterial stiffness, (b) if the relationship between heart rate and PWV is mediated by BP levels and (c) whether their association is affected by the levels of aortic stiffening. Approach: Demographic, hemodynamic, laboratory and clinical data of 1566 subjects from the cross-sectional observational 'Corinthia' study were analyzed using univariate and multivariate regression models. Mediation analysis was performed to test whether mean arterial pressure (MAP) is a significant mediator in the heart rate-PWV relationship. The total population was divided in two groups of low and high arterial stiffness according to the median PWV value (8.6 m s −1 ). Main results: We found that (i) there is a significant association between heart rate and PWV, regardless of other confounding factors. An increase in heart rate by 20 b.p.m. can increase PWV by 0.5 m s −1 . However, this association was significant only for subjects with increased aortic stiffness (PWV > 8.6 m s −1 ) and not for those with PWV ⩽ 8.6 m s −1 . Further, (ii) heart rate-PWV association was partially mediated by MAP. Significance: Increased resting heart rate is related to increased aortic stiffness, only in subjects with stiffer aortas, regardless of BP and other risk factors and subjects' characteristics. The synergistic prognostic effect of increased arterial stiffness and elevated heart rate on target organ damage, cardiovascular events and mortality should be explored in future studies.

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Section: Introductionmentioning

confidence: 99%

The influence of resting heart rate on pulse wave velocity measurement is mediated by blood pressure and depends on aortic stiffness levels: insights from the Corinthia study

et al. 2019

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“…So far limited and conflicting evidence is available on the relation between aPWV and AAA. Some studies showed an increased aPWV [7,10], whereas others showed decreased aPWV in untreated AAA patients [9,17]. Most studies using tonometry were performed in relatively small sample sizes.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies report an increase in arterial stiffness after endovascular aneurysm repair (EVAR), derived from the arterial pulse wave velocity (aPWV) measured over the carotid to femoral artery trajectory or brachial to below-the-knee artery trajectory [7,8,10,[18][19][20]. It has been suggested that this increased stiffness post-EVAR is a risk factor for future cardiovascular adverse events.…”

Section: Introductionmentioning

confidence: 99%

Effect of abdominal aortic endoprostheses on arterial pulse wave velocity in an in vitro abdominal aortic flow model

et al. 2018

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“…In all mixed model analyses, an unstructured correlation structure was assumed. All models were adjusted for sex, race, center, heart rate, current smoking, blood pressure-lowering medication use at visit 5 and the inverse of Mill's ratio [4,29,30]. Age and heart rate were treated as time-varying covariates.…”

Section: Methodsmentioning

confidence: 99%

Longitudinal associations of blood pressure with aortic stiffness and pulsatility: the Atherosclerosis Risk in Communities Study

Metcalf

Meyer

Tanaka

et al. 2021

Journal of Hypertension

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Objective: To characterize the longitudinal relationships between blood pressure measured over 24 years and arterial stiffness in late life measured as pulse wave velocity (PWV).Methods: Carotid-femoral (cf) and femoral-ankle (fa) PWV were measured in 4166 adults at the visit 5 Atherosclerosis Risk in Communities study cohort examination (2011)(2012)(2013). Participants were categorized into tertiles of PWV measurements. Blood pressure measurements were made at baseline (1987)(1988)(1989), three subsequent triennial examinations, and visit 5.Results: Partial correlation coefficients between visit 5 cfPWV and SBP ranged from 0.13 for visit 1 SBP to 0.32 for visit 5 SBP. For visit 5 faPWV, correlations were $0 for visits 1 to 4 SBP, but was 0.20 for visit 5 SBP. Over 24 years of follow-up, those with higher average SBP were more likely to fall in the middle and upper tertiles of visit 5 cfPWV. Average pulse pressure and mean arterial pressure over 24 years had similar but weaker associations with cfPWV tertiles. DBP had no clear association with cfPWV. Blood pressure measurements were positively associated with faPWV tertiles only cross-sectionally at visit 5. Conclusion:Adult life-course measures of SBP, more so than mean arterial and pulse pressure, were associated with later life central arterial stiffness. By contrast, only contemporaneous measures of blood pressure were associated with peripheral arterial stiffness. Although arterial stiffness was only measured at later life, these results are consistent with the notion that elevated blood pressure over time is involved in the pathogenesis of arterial stiffening.

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Response: Heart Rate and Pulse Wave Velocity

Cited by 14 publications

References 0 publications

The influence of resting heart rate on pulse wave velocity measurement is mediated by blood pressure and depends on aortic stiffness levels: insights from the Corinthia study

The influence of resting heart rate on pulse wave velocity measurement is mediated by blood pressure and depends on aortic stiffness levels: insights from the Corinthia study

Effect of abdominal aortic endoprostheses on arterial pulse wave velocity in an in vitro abdominal aortic flow model

Longitudinal associations of blood pressure with aortic stiffness and pulsatility: the Atherosclerosis Risk in Communities Study

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