2008
DOI: 10.1080/03008200802325169
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Response of a Collagenase-Induced Tendon Injury to Treatment with a Polysulphated Glycosaminoglycan (Adequan)

Abstract: This study explored the hypothesis that local administration of a polysulphated glycosaminoglycan (PSGAG) in the early phase of healing of a standard collagenase-induced tendon injury in the superficial digital flexor tendon of the rabbit would reduce the degenerative effects of inflammatory mediators and proteases and preserve normal tendon morphology, composition, and biomechanical properties. Histological and ultrastructural changes together with the mechanical properties, dry weight, collagen content, and … Show more

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Cited by 54 publications
(49 citation statements)
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“…The undifferentiated mesenchymal cells also migrate from the peritendinous tissues and fill the injured area 30 . These cells are activated and differentiated into fibroblasts and endothelial cells by the local growth factors…”
Section: Fibrous Responsementioning
confidence: 99%
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“…The undifferentiated mesenchymal cells also migrate from the peritendinous tissues and fill the injured area 30 . These cells are activated and differentiated into fibroblasts and endothelial cells by the local growth factors…”
Section: Fibrous Responsementioning
confidence: 99%
“…24,25 . Therefore, macrophages have a major role during different phases of tendon healing 26,27 . Growth factors such as vascular endothelial growth factors (VEGF), basic fibroblast growth factors, platelet-derived growth factors and tissue growth factor-β have significant roles in cell differentiation, cell proliferation and tissue maturation and collaborate in all phases of tendon healing with different mechanisms…”
Section: Infiltration and Debridingmentioning
confidence: 99%
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“…These are basically divided into four categories including glycosaminoglycans, growth factors, pro-inflammatory mediators and healing agents [12,30,31]. Glycosaminoglycans are present in the tissue matrix of all the connective tissues [4,9,31,90]. Hyaluronic acid, chondroitin sulphate, dermatan sulphate, keratin sulphate and glucosamine are some examples of this category [1].…”
Section: Healing Promotive Factorsmentioning
confidence: 99%