The current study was carried out during the 2019 Kharif season at the Department of Vegetable Science, Odisha University of Agriculture and Technology (OUAT), Bhubaneswar, to determine the impact of organic manures and chemical fertilizers on the yield attributing characters, quality, and economics of Bottle gourd (Lagenaria Siceraria L.) cv. BBOG-3-1. The experiment consisted of Twelve treatments and three replications. Organic manures, inorganic fertilizers and Bio-fertilizers were used in twelve different treatments. viz.,T1(Control),T2(100% RDF) (80:50:50 Kg NPK ha-1), T3 (FYM @15 t ha-1), T4 (Vermicompost @ 5 t ha-1], T5 (50% RDF + FYM @ 7.5 t ha-1 +Biofertilizer), T6 ( 50%RDF+ Vermicompost@2.5tha-1+ Biofertilizer), T7 (FYM @ 7.5 t ha-1 +Biofertilizer),T8(50%RDF+Biofertilizer),T9(Vermicompost@2.5tha+Biofertilizer),T10(100%RDF+FYM @7.5tha1+Biofertilizer),T11(100%RDF+Vermicompost @ 2.5 t ha-1 + Biofertilizer) and T12(50% RDF + FYM @7.5 t ha-1+ Vermicompost @ 2.5t ha-1+ Biofertilizer), Out of these, an application of 50%RDF+FYM@7.5t ha-1 + Vermicompost @ 2.5t ha-1+ Biofertilizer (T12) had a beneficial effect on minimum days to the first fruit harvest(59.00days), maximum days to last harvest(92.00days), Average Fruit weight(1231g), TSS(4.97ºBrix), Ascorbic acid(8.60 mg100gm-1), Reducing Sugar (3.78%), Non-Reducing Sugar(1.89%), Total Sugar(5.67%),Yield (44.82kg plot-1),Yield(280.13qha-1) and B:C ratio (2.92 ).