2012
DOI: 10.1016/j.nimb.2012.01.032
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Response of cancer stem-like cells and non-stem cancer cells to proton and γ-ray irradiation

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Cited by 18 publications
(20 citation statements)
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“…Although the published data are scarce, it has been reported that CSCs may be more effectively killed by carbon ions compared to photons in colon and pancreas cancers both in vitro and in vivo, [142][143][144] and CSCs from colon and breast cancers may be more efficiently eliminated by proton irradiation than photon treatment, at least in vitro. [145][146][147] These latter findings suggest a higher RBE for CSCs and, hence, a potential therapeutic gain with protons over photon irradiations in tumors where CSCs are a significant resistant population. 148 Additional carefully controlled studies of CSCs treated with protons versus photons are needed.…”
Section: B Novel and Mechanistic Biology Studies To Quantify And Ementioning
confidence: 90%
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“…Although the published data are scarce, it has been reported that CSCs may be more effectively killed by carbon ions compared to photons in colon and pancreas cancers both in vitro and in vivo, [142][143][144] and CSCs from colon and breast cancers may be more efficiently eliminated by proton irradiation than photon treatment, at least in vitro. [145][146][147] These latter findings suggest a higher RBE for CSCs and, hence, a potential therapeutic gain with protons over photon irradiations in tumors where CSCs are a significant resistant population. 148 Additional carefully controlled studies of CSCs treated with protons versus photons are needed.…”
Section: B Novel and Mechanistic Biology Studies To Quantify And Ementioning
confidence: 90%
“…In light of the discussion above about some fraction of human tumor cells having higher RBE values because of DNA repair defects, one might ask whether CSCs have lower proton RBEs. Although the published data are scarce, it has been reported that CSCs may be more effectively killed by carbon ions compared to photons in colon and pancreas cancers both in vitro and in vivo, and CSCs from colon and breast cancers may be more efficiently eliminated by proton irradiation than photon treatment, at least in vitro . These latter findings suggest a higher RBE for CSCs and, hence, a potential therapeutic gain with protons over photon irradiations in tumors where CSCs are a significant resistant population .…”
Section: Recommendations For Future Experimentsmentioning
confidence: 99%
“…Some isolated cancer stem cells show resistance to ionizing radiation treatment. Cancer stem cells have been found to be radiation resistant in breast cancer cell lines (59,60) and glioblastoma (61). Currently this phenotype has not been widely characterized in prostate cancer stem cells.…”
Section: Prostate Cscs and Radiation Resistancementioning
confidence: 99%
“…In related studies, Fu et al [22] selected cancer stemlike and nonstem cells from the breast cancer cell line MCF7, as based on the cells’ expression of the stem cell markers CD44 and CD24. The response of the 2 cell populations to radiation was assessed by the cells’ percentage increase in apoptosis and γ-H2AX foci.…”
Section: Discussionmentioning
confidence: 99%