Response of Citric Acid Levels to Oral Administration of Glucose. I. Normal Adults and Children 1

Abstract

It has been demonstrated in animal and plant tissue studies that citric acid metabolism is intimately related to carbohydrate metabolism (1-5).

Response of Citric Acid Levels to Oral Administration of Glucose. Ii. Abnormalities Observed in the Diabetic and Convulsive State 1

“…In the first paper of this series (1) it was demonstrated in vivo in humans that the normal response to active carbohydrate metabolism, as in the postabsorptive period for glucose, or after injection of insulin, is a lowering of blood citric acid levels.…”

“…For this reason and for the convenience of the patient, we discarded the six-hour test and substituted a three-hour test, seeking the contour of the first half of the citric acid curve. 1 Presented in part at the Meeting of the American Chemical Society, New York City, Sept. 15, 1947. In order to see the effect of a disturbed insulin balance on citric acid levels we applied this study to diabetic adults. A large majority of diabetics exhibited a citric acid response which was not markedly different from that of the normal.…”

Concentration of sugars, ketone bodies and some organic acids in udder lymph and plasma of cattle

“…Pyruvic acid and a-oxoglutaric acid were ,estimated by chromatography of the 2:4-dinitrophenylhydrazones (Cavallini & Mondovi, 1957); the solvent systems phenol (Partridge, 1948) and 0.1 N-glycine buffer, pH 8-4 (Virtanen, Miettinen & Kunttu, 1953), were used. -Citric acid and lactic acid were determined by the method of Natelson, Pincus & Lugovoy (1948) (Heyndrickx, 1959).…”

Действие Мелатонина На Активность Аконитатгидратазы, Содержание Продуктов Липопероксидации И Некоторых Неферментативных Антиоксидантов В Крови Больных Сахарным Диабетом 2 Типа, Осложненным Стеатогепатитом

“…Äëÿ îïðåäåëåíèÿ ñîäåðaeàíèÿ a-òîêîôåðîëà èñïîëüçî-âàëè ìåòîä, îñíîâàííûé íà ôîòîìåòðèðîâàíèè õðîìî-ãåííîãî êîìïëåêñíîãî ñîåäèíåíèÿ Fe 2+ , îáðàçóþùåãî-ñÿ ïðè âçàèìîäåéñòâèè a-òîêîôåðîëà ñ FeCl 3 è îðòî-ôåíàíòðîëèíà [15]. Êîëè÷åñòâî öèòðàòà îïðåäåëÿëè ïî ìåòîäó Íàòåëüñîíà [16]. Îáùèé áåëîê îïðåäåëÿëè óíèôèöèðîâàííûì ìåòîäîì ïî áèóðåòîâîé ðåàêöèè [8].…”