2018
DOI: 10.1080/09712119.2018.1434078
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Response of cyclophosphamide-treated broiler chickens to challenge with velogenic Newcastle disease virus

Abstract: This study investigated whether prior cyclophosphamide (CY) treatment influenced the susceptibility of young broiler chickens to velogenic Newcastle disease (vND) virus (vNDV) challenge. Broiler chickens treated with CY at 4 weeks of age showed a loss of weight, severe atrophy of the bursa and thymus and severe lymphocytic depletion in the bursa, spleen and thymus and lymphopaenia. On challenge at 6 weeks of age with vNDV, there were significant (p < .05) weight loss, severe depression, diarrhoea, coughing and… Show more

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Cited by 9 publications
(6 citation statements)
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“…No significant (p>0.05) reduction was observed in the erythrocytic parameters in the NDV-challenged group, which could be due to the acute nature of infection induced by the velogenic KUDU 113 virus and the ability of vaccination and vitamin supplementation to prevent the destruction of the RBC. This was similarly observed by [43,44]. Furthermore, the nonsignificant increase in the total WBC is usually due to heterophilia and shows the severity of the inflammatory process in NDV infections [44].…”
Section: Discussionsupporting
confidence: 53%
“…No significant (p>0.05) reduction was observed in the erythrocytic parameters in the NDV-challenged group, which could be due to the acute nature of infection induced by the velogenic KUDU 113 virus and the ability of vaccination and vitamin supplementation to prevent the destruction of the RBC. This was similarly observed by [43,44]. Furthermore, the nonsignificant increase in the total WBC is usually due to heterophilia and shows the severity of the inflammatory process in NDV infections [44].…”
Section: Discussionsupporting
confidence: 53%
“…It affects a wide range of poultry, cage and wild birds (Cattoli et al 2011). Chickens are the most susceptible and it is only in this specie that ND produces haemorrhagic and ulcerative lesions in the gastrointestinal tract (Igwe et al 2018a). Turkeys are less susceptible (Okoroafor et al 2018).…”
Section: Introductionmentioning
confidence: 99%
“…They cause mainly the respiratory form of ND. The velogenic pathotype causes the most devastating form of ND with mortalities of 70% to 100% within 7 days in susceptible chickens (Igwe et al 2018a). The isolates are found worldwide in poultry and wild birds.…”
Section: Introductionmentioning
confidence: 99%
“…Improper handling, transportation and storage of these vaccines especially under the present incessant power failure in Nigeria could lead to loss of potency. Studies of lesions and mortalities of ND have shown that the strain of ND in Nigeria is comparatively very virulent (Igwe et al, 2018a). It is therefore possible that the vaccine failures could be as a result of vaccine immunity being overcome by over large dose of very virulent field strain of the virus.…”
Section: Discussionmentioning
confidence: 99%
“…Based on the virulence for chickens, five pathotypes have been distinguished: asymptomatic, lentogenic, mesogenic, neurotropic velogenic, and viscerotropic velogenic (OIE, 2012). Infection with virulent Newcastle disease virus (vNDV) has been associated with severe systemic disease and accompanied by high morbidity and with 100% mortality in poultry (Okoye et al,2000;Miller & Koch,2013;Igwe et al, 2018a).Therefore, ND is a major threat to food security in many countries, especially in areas of Africa, Asia, the Middle East, and in some countries of North, Central and South America, causing recurrent outbreaks in poultry production facilities resulting in considerable economic impact Shittu et al, 2016). Different approaches and measures have been adopted to control the spread of ND in many parts of the world.…”
Section: Introductionmentioning
confidence: 99%