Response of Digestive Carbohydrases and Growth to Graded Doses and Administration Frequency of Hydrocortisone and Adrenocorticotropic Hormone in Nursing Piglets

Chapple, Richard P.; Cuarón, José A.; Easter, R. A.

doi:10.2527/jas1989.67112974x

Cited by 12 publications

(2 citation statements)

References 20 publications

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“…Despite the minimal effects observed on immune function, ample evidence was found of the systemic effects of high doses of glucocorticoids in Experiment 1. The decreased growth rate observed has been previously reported in piglets treated with glucocorticoids (Chappie et al 1989a;Chappie et al 1989b). Hepatomegaly is often seen in animals suffering from hyperadrenocorticism, (Feldman, 1989;Haynes, 1990) and has been reported in pigs receiving hydrocortisone (Chappie et al 1989a;Chappie et al 1989b).…”

Section: Discussionmentioning

confidence: 60%

“…The decreased growth rate observed has been previously reported in piglets treated with glucocorticoids (Chappie et al 1989a;Chappie et al 1989b). Hepatomegaly is often seen in animals suffering from hyperadrenocorticism, (Feldman, 1989;Haynes, 1990) and has been reported in pigs receiving hydrocortisone (Chappie et al 1989a;Chappie et al 1989b). The increased liver size may have resulted from increased glycogen stores due to the gluconeogenic effect of dexamethasone (Feldman, 1989;Haynes, 1990).…”

Section: Discussionmentioning

confidence: 69%

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Evaluating immune function in domestic animals

Flaming

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Introduction Materials and Methods Results Discussion References GENERAL SUMMARY iv ACKNOWLEDGEMENTS People have helped me in all of my major life endeavors. My Ph.D. is no exception. The nature of the research contained in this dissertation made the involvement of many people a necessity. Andrea Dom performed most of the lymphocyte blastogenesis work. She was also responsible for the large task of keeping the lab running: making sure things were ready and available. You do a wonderful job Andrea. Dagmar Frank performed most of the neutrophil fiinction assays. As with anyone who is good at what they do, Dagmar makes it look easy. It isn't; I've tried to fill in for her on occasion. Thanks Dagmar. Tom Skadow is now head neutrophil isolator and animal handler. Tom also plays a large role with Andrea in keeping the lab running. In addition, Tom played the important role of entertaining steer #340 on occasion. Your work is really appreciated Tom. Darl Enga, Tim, and others have all helped out washing dishes and bleeding animals. Their work makes the rest of us more efficient at what we do. Thanks y'all. Belinda Goff played a leading role in the first pig/dexamethasone experiment. She was the QAC (quality assurance coordinator) that kept us on the GLP path. Of course, she was the point person in organizing that experiment as well. Thanks BG. Vicky Hall was very helpful in getting me started in flow cytometry. Kristy Harkins has been instrumental in overseeing all of the flow work for the BIV animals. Thanks also Kristy for taking an interest in me. Thanks to Padma and JefT for running the many samples. Susan Carpenter has been an integral part of the BIV project. She brings an enthusiasm and drive to the project. I have also learned to appreciate the virologist's perspective from her. Thanks to Susan, Mary Jane Long, and Yvonne Wannemuehler for their work on virus isolation and testing. Cecelia Whetstone performed the ELISAs that are V reported in the first set of BFV experiments. She also performed the early Western Blot analyses for HIV. Thanks to Martin Van Der Maaten for discovering this virus so I would have a Ph.D. project to work on. Dr. Van Der Maaten has helped with animal housing, providing virus testing, reagents, virus stocks, discussions, animals, and other things as well. I would also like to thank him for showing me that science can be fun, or at least humorous. Jeff Isaacson has also been part of the BIV team. Thanks for the discussions Jeff. Anna Rovid has been a co-sufferer on the BFV project. She is the macrophage expert. Thanks for the support, friend. I've learned lots from you and most of it had to do with life, not science. Jim Roth, Thanks Jim. When people ask me for advice on selecting a graduate school program I tell them to look for a good major professor. When I came to interview here everyone had wonderful things to say about you. The one negative comment I heard was that you were kinda busy and sometimes hard to find, but you would always make time for your students. Well it was true, and...

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 69%

Evaluating immune function in domestic animals

Flaming

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Pigs are relatively resistant to dexamethasone induced immunosuppression

et al. 1994

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Cortisol increases the activities of intestinal apical membrane hydrolases and nutrient transporters before weaning in mink (Mustela vison)

Elnif¹,

Buddington

Hansen³

et al. 2005

J Comp Physiol B

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Glucocorticoids from endogenous and exogenous sources accelerate maturation of brush-border membrane (BBM) hydrolases in omnivorous laboratory rodents and pigs. Less is known for carnivores, and whether the route of administration (oral or systemic) has an influence. The present study examined the influence of administering cortisol (hydrocortisone succinate, 5 mg/kg-day) to mink during postnatal week 4, just prior to weaning, on small intestine glucose and amino acid (aspartate, leucine, lysine, methionine, proline) absorption and on the activities of BBM disaccharidases and peptidases. Kits treated with cortisol were smaller (P<0.05), but had small intestines that were proportionally larger (P<0.05 for length and mass per kg body weight, but not for mucosal mass) than control kits with higher rates of absorption for most nutrients, except leucine, and increased activities of most BBM hydrolases, except lactase. As a consequence, cortisol increased hydrolytic and absorptive capacities of the entire small intestine, with the responses more pronounced when the cortisol was given orally. These findings indicate administration of cortisol stimulates growth of the developing mink small intestine, but does not accelerate the postnatal declines in nutrient transport, and may be a dam-to-kit signal that prepares suckling mink to digest and absorb the adult diet.

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Response of Digestive Carbohydrases and Growth to Graded Doses and Administration Frequency of Hydrocortisone and Adrenocorticotropic Hormone in Nursing Piglets

Cited by 12 publications

References 20 publications

Evaluating immune function in domestic animals

Evaluating immune function in domestic animals

Pigs are relatively resistant to dexamethasone induced immunosuppression

Cortisol increases the activities of intestinal apical membrane hydrolases and nutrient transporters before weaning in mink (Mustela vison)

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