Response of DNA ploidy to chemotherapy in primary and metastatic lesions in human osteosarcomas

Kusuzaki, Katsuyuki; Hashiguchi, Shin; Hirata, Masaaki; Takeshita, Hideyuki; Murata, Hiroaki; Ashihara, Tsukasa; Hirasawa, Yasusuke

doi:10.1016/s0304-3835(98)00389-9

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…On the one hand, some studies showed that metastases were high similar to their matched primary cancers at the levels of cytologic features [25,26], cytogenetic alterations [27][28][29][30][31][32][33][34][35], DNA changes including aneuploidy, and index [36][37][38][39][40][41][42], gene analyses including mutations [43][44][45][46][47][48][49][50][51][52][53], profiles [18,[54][55][56][57], and epigenetic and transcriptive changes [58][59][60][61][62], proteomic profiling [61,63] and expression [64][65][66][67][68][69][70][71]…”

Section: Similarities Between Primary Tumors and Matched Metastases Amentioning

confidence: 99%

Biological resonance for cancer metastasis, a new hypothesis based on comparisons between primary cancers and metastases

Gao

2013

Cancer Microenvironment

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Many hypotheses have been proposed to try to explain cancer metastasis. However, they seem to be contradictory and have some limitations. Comparisons of primary tumors and matched metastases provide new insight into metastasis. The results show high concordances and minor differences at multiple scales from organic level to molecular level. The concordances reflect the commonality between primary cancer and metastasis, and also mean that metastatic cancer cells derived from primary cancer are quite conservative in distant sites. The differences reflect variation that cancer cells must acquire new traits to adapt to foreign milieu during the course of evolving into a new tumor in second organs. These comparisons also provided new information on understanding mechanism of vascular metastasis, organ-specific metastasis, and tumor dormancy. The collective results suggest a new hypothesis, biological resonance (bio-resonance) model. The hypothesis has two aspects. One is that primary cancer and matched metastasis have a common progenitor. The other is that both ancestors of primary cancer cells and metastatic cancer cells are under similar microenvironments and receive similar or same signals. When their interactions reach a status similar to primary cancer, metastasis will occur. Compared with previous hypotheses, the bio-resonance hypothesis seems to be more applicable for cancer metastasis to explain how, when and where metastasis occurs. Thus, it has important implications for individual prediction, prevention and treatment of cancer metastasis.

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Section: Similarities Between Primary Tumors and Matched Metastases Amentioning

confidence: 99%

Biological resonance for cancer metastasis, a new hypothesis based on comparisons between primary cancers and metastases

Gao

2013

Cancer Microenvironment

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DNA cytofluorometric analysis of chondrocytes in human articular cartilages under normal aging or arthritic conditions

Kusuzaki¹,

Sugimoto²,

Takeshita³

et al. 2001

Osteoarthritis and Cartilage

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Osteosarcomas and other cancers of bone

Bramwell¹

2000

Current Opinion in Oncology

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The results of several studies suggest that alterations in various cell cycle regulatory genes are involved in the pathogenesis of osteosarcomas. Experiments in animal models provide preliminary data on the feasibility of gene therapy in osteosarcoma and chondrosarcoma. Prediction of response to chemotherapy remains a major focus of imaging research. Several clinicopathologic studies have explored the mechanisms underlying multidrug resistance in osteosarcoma patients receiving neoadjuvant chemotherapy. HER2/erbB2 expression, linked to poor prognosis, has been proposed as a therapeutic target in osteosarcoma. In clinical studies of osteosarcoma, further data confirm the activity of ifosfamide and carboplatin but provide little support for the use of immunotherapy. A retrospective analysis showed no value for dose intensification of doxorubicin/cisplatin, but the results of a prospective trial should be more informative. Recent evidence confirms that secondary osteosarcomas and malignant fibrous histiocytomas of bone should be treated with aggressive chemotherapy regimens, similar to those used for osteosarcomas.

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Response of DNA ploidy to chemotherapy in primary and metastatic lesions in human osteosarcomas

Cited by 4 publications

References 19 publications

Biological resonance for cancer metastasis, a new hypothesis based on comparisons between primary cancers and metastases

Biological resonance for cancer metastasis, a new hypothesis based on comparisons between primary cancers and metastases

DNA cytofluorometric analysis of chondrocytes in human articular cartilages under normal aging or arthritic conditions

Osteosarcomas and other cancers of bone

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