Response of Human Dental Pulp Capped with MTA and Calcium Hydroxide Powder

Accorinte, Maria de Lourdes Rodrigues; Loguércio, Alessandro Dourado; Reis, Alessandra; Carneiro, Everdan; Murata, Sueli Satomi; Holland, R

doi:10.2341/07-143

Cited by 87 publications

(87 citation statements)

References 22 publications

(32 reference statements)

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“…This is an important finding, since it is known that all materials can induce different levels of acute inflammation in the pulp. 3,4 Moreover, Single Bond was able to induce a significantly higher secretion of IL-8 than MTA. Since IL-8 is a potent neutrophil chemotactic protein, secretion of this cytokine by migrating neutrophils was expected.…”

Section: Discussionmentioning

confidence: 99%

“…2 Pulp capping materials are largely used in dental practice to promote dental pulp repair, especially materials based on calcium hydroxide [Ca(OH) 2 ], adhesive systems and, more recently, mineral trioxide aggregates (MTA). 3 Traditionally, various formulations of Ca(OH) 2 -containing materials represent the most usual types of capping treatment. However, the physical limitations of these materials have led researchers and clinicians to seek new materials.…”

Section: Introductionmentioning

confidence: 99%

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Pulp capping materials exert an effect on the secretion of IL-1β and IL-8 by migrating human neutrophils

et al. 2011

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Pulp repair is a complex process whose mechanisms are not yet fully understood. The first immune cells to reach the damaged pulp are neutrophils that play an important role in releasing cytokines and in phagocytosis. The objective of this study was to analyze the effect of different pulp-capping materials on the secretion of interleukin-1 beta (IL-1β) and interleukin-8 (IL-8) by migrating human neutrophils. Neutrophils were obtained from the blood of three healthy donors. The experimental groups were calcium hydroxide [Ca(OH) 2 ], an adhesive system (Single Bond), and mineral trioxide aggregate (MTA). Untreated cells were used as control. Transwell chambers were used in performing the assays to mimic an in vivo situation of neutrophil chemotaxis. The pulpcapping materials were placed in the lower chamber and the human neutrophils, in the upper chamber. The cells were counted and the culture medium was assayed using ELISA kits for detecting and quantifying IL-1β and IL8. The data were compared by ANOVA followed by Tukey's test (p < 0.05). The secretion of IL-8 was significantly higher in all groups in comparison to the control group (p < 0.05). The adhesive system group showed higher IL-8 than the MTA group (p < 0.05). The secretion of IL-1β was significantly greater only in the MTA group (p < 0.001). It was concluded that only MTA is able to improve the secretion of IL-1β, and all materials tested increased IL-8 secretion. These results combined with all the other biological advantages of MTA indicate that it could be considered the material of choice for dental pulp capping.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pulp capping materials exert an effect on the secretion of IL-1β and IL-8 by migrating human neutrophils

et al. 2011

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“…It stimulates reparative dentine formation faster and thicker than calcium hydroxide cement. However, MTA has delayed setting time, poor handling characteristics and is relatively expensive (4) .…”

Section: The Effect Of Incorporating Nanocalcium Phosphate Particles mentioning

confidence: 99%

The Effect of Incorporating Nanocalcium Phosphate Particles into Biodentine on Pulpal Tissue Response (In Vitro Study)

Aidaros

Niazy²,

El-yassaky

2018

ADJ-for Girls

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Objectives: This study was conducted to evaluate the effect of incorporating Nanocalcium phosphate (NCP) particles into Biodentine™ on pulpal tissue response as a direct pulp capping material (entire tooth culture model). Materials and methods: -A total of forty freshly human premolar teeth extracted for orthodontic reasons were used. After cavity preparation and mechanical pulp exposure, the teeth were divided into 2 main groups (20 teeth each) according to the capping material used; where group (M1) refers to pulps capped with Biodentine™, and group (M2) refers to pulps capped with Biodentine incorporated with NCP. Each group was further subdivided into two subgroups according to the culture period; where subgroup (P1) refers to teeth cultured for 14 days, and subgroup (P2) refers to teeth cultured for 28 days. At the end of each culture period, the teeth were histologically examined to assess the dentine bridge thickness of each group after 14 and 28 days. Moreover, elemental analysis of Calcium and Phosphorous ions in the dentine bridge was performed using SEM-EDX. Results: Direct pulp capping with Biodentine incorporated with NCP showed thicker dentine bridge when compared to Biodentine™ alone. There is a positive correlation between the weight % of Calcium and Phosphorous ions in the dentine bridge below both capping materials and the dentine bridge thickness. Conclusion: Biodentine incorporated with NCP could be a good candidate for pulp capping in the future.

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“…We had selected Ca as a control in vivo experiment. Dentin bridge formation in calcium hydroxide showed faster compared to MTA 36) . In the clinical case, exposed pulp should be closed by the complete dentin bridge in a short period.…”

Section: Discussionmentioning

confidence: 86%

The possibility of genistein as a new direct pulp capping agent

et al. 2013

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Genistein, kind of soy isoflavones, is well-known as natural ingredients and consumed as health foods and supplements. They are expected to improve renal function. They have high-affinity to estrogen receptor β expressed predominantly in bone tissue, they prevent osteoporosis specifically and safely. We examined whether genistein can be a new direct capping agent. In this study, we examined the effect of genistein for the proliferation and differentiation of rat dental pulp cells in vitro and the ability of tertiary dentin formation in vivo. As a result, rat dental pulp cells with genistein were increased activity of ALPase and showed alizarin red positive-staining. Calcification-related genes expression has been confirmed by the addition of genistein. From in vivo study, high quality of tertiary dentin formation and minor pulp reaction were observed. From these findings, it was suggested that genistein may be useful agent for direct pulp capping.

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Response of Human Dental Pulp Capped with MTA and Calcium Hydroxide Powder

Cited by 87 publications

References 22 publications

Pulp capping materials exert an effect on the secretion of IL-1β and IL-8 by migrating human neutrophils

Pulp capping materials exert an effect on the secretion of IL-1β and IL-8 by migrating human neutrophils

The Effect of Incorporating Nanocalcium Phosphate Particles into Biodentine on Pulpal Tissue Response (In Vitro Study)

The possibility of genistein as a new direct pulp capping agent

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