Response of latent syphilis or neurosyphilis to ceftriaxone therapy in persons infected with human immunodeficiency virus

Dowell, Mark E.; Ross, Paul G.; Musher, Daniel M.; Cate, Thomas R.; Baughn, Robert E.

doi:10.1016/0002-9343(92)90574-u

Cited by 126 publications

(82 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With minor differences, the recommended treatment and outcome of HIV-infected and uninfected patients are similar. 95,96 Among HIV-infected patients, the lack of appropriate decline in the titers has been the basis for pre- sumed increased rates of therapeutic failure. Recently, ceftriaxone was suggested as an alternative to penicillin, but high failure rates were seen in HIV-infected patients.…”

Section: Interpretation Of Serological Test Results During Follow-upmentioning

confidence: 99%

Syphilis in the United States: An Update for Clinicians With an Emphasis on HIV Coinfection

Zetola

Engelman

Jensen

et al. 2007

Mayo Clinic Proceedings

114

View full text Add to dashboard Cite

Diagnosis and treatment of syphilis are challenging because of its variable clinical presentation and course and the lack of definitive tests of cure after treatment. This review of the most recent literature on the epidemiology, clinical manifestations, current diagnosis, and treatment of syphilis is focused toward clinicians who treat patients with this disease. Syphilis coinfection with human immunodeficiency virus is emphasized because it is increasingly common in the United States and affects the initial presentation, disease course, diagnosis, and treatment of syphilis. Of particular consequence is the effect of human immunodeficiency virus on the clinical diagnosis, prevalence, and course of neurosyphilis, one of the most serious consequences of syphilis infection. linicians from large metropolitan areas frequently face the challenge of diagnosing syphilis and treating patients with syphilis. In doing so, they are often faced with questions regarding interpretation of clinical findings and laboratory results and selection of appropriate therapy. Interpretation of the data available to answer these questions is often challenging given the paucity of large well-designed studies and the substantial variability that characterizes the clinical presentation of syphilis. Such a challenge is particularly found in the treatment of patients coinfected with syphilis and human immunodeficiency virus (HIV). To guide clinicians in this difficult task, we discuss the most recent literature on the epidemiology, clinical manifestations, diagnosis, and treatment of syphilis and the corresponding effects of HIV coinfection.

show abstract

Section: Interpretation Of Serological Test Results During Follow-upmentioning

confidence: 99%

Syphilis in the United States: An Update for Clinicians With an Emphasis on HIV Coinfection

Zetola

Engelman

Jensen

et al. 2007

Mayo Clinic Proceedings

114

View full text Add to dashboard Cite

show abstract

“…Nowe antybiotyki krętkobójcze to m.in. ceftriakson podawany domięśniowo lub dożylnie [71,72]. Cef triakson dobrze penetruje do PMR, ale wymagane są wielokrotne iniekcje, dawki i czas leczenia nie są wystandaryzowane i nie ma on przewagi nad pojedynczą dawką BPG [73].…”

Section: Badania W Celu Rozpoznania Kiły Narządu Słuchuunclassified

2014 European guideline on the management of syphilis

Janier¹,

Hegyi²,

Dupin³

et al. 2015

View full text Add to dashboard Cite

“…Alternative therapy, including ceftriaxone at 1 g per day, is equally effective and can be administered far more easily. Both of these regimens are associated with rates of failure plus relapse that approach 30% (22,34). It is entirely possible that daily procaine penicillin for 10 to 14 days would be as effective.…”

Section: Treatmentmentioning

confidence: 99%

Secondary Syphilitic Lesions

2005

Self Cite

View full text Add to dashboard Cite

An important theme that emerges from all early historical accounts is that in addition to the decreased virulence of Treponema pallidum, the incidence of secondary syphilis has decreased drastically over the past three centuries. Even in the early 20th century, most syphilologists were of the opinion that the disease had undergone changes in its manifestations and that they were dealing with an attenuated form of the spirochete. Such opinions were based primarily on the observations that violent cutaneous reactions and fatalities associated with the secondary stage had become extremely rare. The rate of primary and secondary syphilis in the United States increased in 2002 for the second consecutive year. After a decade-long decline that led to an all-time low in 2000, the recent trend is attributable, to a large extent, by a increase in reported syphilis cases among men, particularly homosexual and bisexual men having sex with men. The present review addresses the clinical and diagnostic criteria for the recognition of secondary syphilis, the clinical course and manifestations of the disease if allowed to proceed past the primary stage of disease in untreated individuals, and the treatment for this stage of the disease

show abstract

Response of latent syphilis or neurosyphilis to ceftriaxone therapy in persons infected with human immunodeficiency virus

Cited by 126 publications

References 36 publications

Syphilis in the United States: An Update for Clinicians With an Emphasis on HIV Coinfection

Syphilis in the United States: An Update for Clinicians With an Emphasis on HIV Coinfection

2014 European guideline on the management of syphilis

Secondary Syphilitic Lesions

Contact Info

Product

Resources

About