Response of Layer Breeders to Dietary Acetylsalicylic Acid. 2. Effects on Circulating Concentrations of Prostaglandin F2α

Balog, J. M.; McDaniel, C. D.; Freed, Marisue; Elkin, Robert G.; Wellenreiter, R. H.; Hester, Patricia Y.

doi:10.3382/ps.0721093

Cited by 5 publications

(2 citation statements)

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“…In fact, hens fed ASA (.025 to .400% of the diet) laid hard-shelled eggs of poorer shell quality than controls (McDaniel et al, 1993a). Circulating concentrations of PGF2 a in 26-wk-old layer breeders were not affected by acute (7 days) or chronic (28 days) feeding of either .05 or .40% ASA (Balog et al, 1993). Thus, it appears that dietary ASA is probably ineffective as a uterine anti-PG agent in 6 NEN Research Products, Wilmington, DE 19805.…”

Section: Introductionmentioning

confidence: 78%

“…Recently, ASA was fed to layer breeders to determine whether the improvement in egg production noted by Reid et al (1964), Thomas et al (1966), and Oluyemi and Adebanjo (1979) was due to its anti-PG properties rather than its antipyretic properties (Balog and Hester, 1991;Balog et al, 1993;McDaniel et al, 1993a). Because many eggs are laid prematurely, resulting in the production of eggs that are soft-shelled (partially calcified) or shell-less (little to no calcification), ASA may inhibit uterine production of PG, thereby preventing the premature oviposition of some of these defective eggs .…”

Section: Introductionmentioning

confidence: 99%

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Response of Layer Breeders to Dietary Acetylsalicylic Acid.

et al. 1993

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Acetylsalicylic acid (ASA), the active ingredient of aspirin, has been evaluated as a potential feed ingredient in laying hen rations because of its antipyretic and antiprostaglandin properties. Therefore, the present study was designed to determine whether dietary ASA or its metabolites are transferred to the egg.A single oral dose of 14 C-carboxyl-labeled ASA administered to White Leghorn hens resulted in eggs containing approximately .02% of the administered dose. More 14 C-label was found in the first egg laid than in subsequent eggs laid, and more 14 C-label was detected in the albumen than in the yolk when eggs were analyzed on an entire egg component basis. The distribution of the * 4 C-label changed markedly with each egg laid, as 96.5,33.5, and 12.0% of the radioactivity was present in the albumen in the first three eggs laid following dosing. Conversely, 3.5, 66.5, and 88.0% of the egg radioactivity was present in the yolk of the first three eggs laid postdosing. White Leghorn breeder hens fed .100, .200, and .400% ASA for an entire (13 mo) production cycle laid eggs containing measurable amounts of salicylic acid (SA, the major metabolite of ASA) in the albumen and yolk, with no detectable levels found in eggs of hens fed 0, .025, and .050% ASA. Again, more SA was detected in the albumen than in the yolk, when expressed either on a per gram or entire egg component basis, from hens fed .200 and .400% ASA. Thus, it appears that ASA can be fed to hens at dietary levels of .05% or lower for an entire production cycle without detectable accumulation (<5 ppm) of SA in the egg yolk or albumen.(

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Section: Introductionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Response of Layer Breeders to Dietary Acetylsalicylic Acid.

et al. 1993

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The effect of acetylsalicylic acid and cold stress on the susceptibility of broilers to the ascites syndrome

Shlosberg

Bellaïche²,

Hanji³

et al. 1996

Avian Pathology

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Pharmacokinetics of Repeated Sodium Salicylate Administration to Laying Hens: Evidence for Time Dependent Increase in Drug Elimination from Plasma and Eggs

et al. 2015

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Salicylates were the first non-steroid anti-inflammatory drugs (NSAIDs) to be used in any species and are still widely used in humans and livestock. However, the data on their pharmacokinetics in animals is limited, especially after repeated administration. Evidence exist that in chickens (Gallus gallus) salicylate (SA) may induce its own elimination. The aim of this study was to investigate salicylate pharmacokinetics and egg residues during repeated administration of sodium salicylate (SS) to laying hens. Pharmacokinetics of SA was assessed during 14 d oral administration of SS at daily doses of 50 mg/kg and 200 mg/kg body weight to laying hens. On the 1st, 7th and 14th d a 24 h-long pharmacokinetic study was carried out, whereas eggs were collected daily. Salicylate concentrations in plasma and eggs were determined using high-performance liquid chromatography with ultraviolet detection and pharmacokinetic variables were calculated using a non-compartmental model. Mean residence time (MRT), minimal plasma concentration (Cmin, C16h) and elimination half-life (T1/2el) of SA showed gradual decrease in layers administered with a lower dose. Total body clearance (ClB) increased. Layers administered with the higher dose showed a decrease only in the T1/2el. In the low dose group, SA was found only in the egg white and was low throughout the experiment. Egg whites from the higher dose group showed initially high SA levels which significantly decreased during the experiment. Yolk SA levels were lower and showed longer periods of accumulation and elimination. Repeated administration of SS induces SA elimination, although this effect may differ depending on the dose and production type of a chicken. Decreased plasma drug concentration may have clinical implications during prolonged SS treatment.

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Response of Layer Breeders to Dietary Acetylsalicylic Acid. 2. Effects on Circulating Concentrations of Prostaglandin F2α

Cited by 5 publications

References 36 publications

Response of Layer Breeders to Dietary Acetylsalicylic Acid.

Response of Layer Breeders to Dietary Acetylsalicylic Acid.

The effect of acetylsalicylic acid and cold stress on the susceptibility of broilers to the ascites syndrome

Pharmacokinetics of Repeated Sodium Salicylate Administration to Laying Hens: Evidence for Time Dependent Increase in Drug Elimination from Plasma and Eggs

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