Response of linear porokeratosis to photodynamic therapy in an 11-year-old girl

Garrido‐Colmenero, Cristina; Ruiz‐Villaverde, Ricardo; Martínez‐García, Eliseo; Aneiros‐Fernández, José; Sánchez, Jesús Tercedor

doi:10.3315/jdcr.2015.1220

Cited by 8 publications

(9 citation statements)

References 5 publications

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“…Garrido‐Colmenero et al . treated an 11‐year‐old girl with linear porokeratosis on her breast with two MAL‐PDT sessions. After treatment, there were only a few remaining lesions at four‐month follow‐up.…”

Section: Methodsmentioning

confidence: 99%

Photodynamic therapy for dermatologic conditions in the pediatric population: a literature review

Kumar

Warren

2017

Photoderm Photoimm Photomed

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Summary Photodynamic therapy (PDT), using topical aminolevulinic acid (ALA), has been used for years to treat a variety of dermatologic conditions, including actinic keratosis, superficial basal cell carcinoma, and in situ squamous cell carcinoma. While there is a wide range of neoplastic and non‐neoplastic skin diseases for which ALA‐PDT is used in adults, there is a knowledge gap when it comes to its use in children. This review highlights what is currently known regarding the use and efficacy of this therapy in the pediatric population. A PubMed search was conducted to identify studies including pediatric patients undergoing monotherapy PDT with topical aminolevulinate (published 2005–2016). Twenty pediatric articles were identified. ALA‐PDT has been used successfully in children to reduce the number and size of basal cell tumors, inflammatory acne lesions, plantar warts, and linear porokeratoses. ALA‐PDT may be an attractive alternative to surgery for children with basal cell nevus syndrome, or to conventional destructive and/or topical methods used for plantar warts or linear porokeratoses. PDT can be considered for inflammatory acne when topical treatments have failed and systemic medications are not an option. Pain associated with treatment and insurance coverage may be a barrier to use.

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Section: Methodsmentioning

confidence: 99%

Photodynamic therapy for dermatologic conditions in the pediatric population: a literature review

Kumar

Warren

2017

Photoderm Photoimm Photomed

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“…28,29 Pain, tenderness, erythema, crusting, and most importantly, incomplete lesion clearance, have all been associated with PDT for LP. 30…”

Section: Therapymentioning

confidence: 99%

A Review of Therapeutic Options for Linear Porokeratosis

Verma,

M. K. Shalabi,

C. Hartmann

et al. 2024

J of Skin

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Linear porokeratosis (LP) is a rare and uncommon variant of porokeratosis presenting as linear annular papules or plaques along Blaschko’s lines. It may arise spontaneously, although evidence of genetic predisposition exists via point mutations in the mevalonate pathway of cholesterol biosynthesis. Malignant transformation is the most serious complication of this chronic, progressive dyskeratosis. We review the currently available treatment options for LP, including topical, systemic, laser, photodynamic, and surgical therapies.

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“…There are three reports on the use of MAL-PDT in LP [406,418,419]. Two adolescent patients underwent this treatment (2-3 sessions at 4-week intervals) after superficial skin stripping.…”

Section: Treatmentmentioning

confidence: 99%

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

Pietkiewicz,

Korecka,

Salwowska

et al. 2023

Metabolites

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Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porokeratosis (also known as genitogluteal porokeratosis), follicular porokeratosis and porokeratoma. Apart from the clinical presentation and epidemiology of each variant listed, this review aims at providing up-to-date information on the precise genetic background, introduces imaging methods facilitating the diagnosis (conventional and ultraviolet-induced fluorescence dermatoscopy, reflectance confocal microscopy and pathology), discusses their oncogenic potential and reviews the literature data on the efficacy of the treatment used, including the drugs directly targeting the isoprenoid–mevalonate pathway.

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Response of linear porokeratosis to photodynamic therapy in an 11-year-old girl

Cited by 8 publications

References 5 publications

Photodynamic therapy for dermatologic conditions in the pediatric population: a literature review

Photodynamic therapy for dermatologic conditions in the pediatric population: a literature review

A Review of Therapeutic Options for Linear Porokeratosis

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

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