Response of Low Birthweight Infants to Treatment with Folic Acid

Burland, W. L.; Simpson, Kate; Lord, Juliet

doi:10.1136/adc.46.246.189

Cited by 40 publications

(20 citation statements)

References 17 publications

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“…However, in this age group as well, Hb appears to respond poorly to folate supplementation. In Britain, parenteral folic acid 61 and oral folic acid 81 given to low birth weight infants failed to improve Hb concentrations, while in a third trial 82 , oral folic acid (100 mg) appeared to temper the decline in Hb at 8 weeks and signi®cantly increase Hb by 23 g l -1 at 6 months. However, the folate group had signi®cantly higher Hb levels at baseline, the infants were not randomized, and the groups were fed differently 82 .…”

Section: Folatementioning

confidence: 99%

The role of vitamins in the prevention and control of anaemia

Fishman

Christian

West

2000

Public Health Nutr.

265

208

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Objective: While iron de®ciency is regarded as the major cause of nutritional anaemia, changes in vitamins A, B 12 , C and E, folic acid and ribo¯avin status have also been linked to its development and control. This paper provides a systematic review of vitamin supplementation trials relating to the control of nutritional anaemia. Methods: A MEDLINE search was used to ®nd reports of vitamin supplementation trials that reported changes in anaemia or iron status. Results: Vitamin A can improve haematological indicators and enhance the ef®cacy of iron supplementation. Both folate and vitamin B 12 can cure and prevent megaloblastic anaemia. Ribo¯avin enhances the haematological response to iron, and its de®ciency may account for a signi®cant proportion of anaemia in many populations. Vitamin C enhances the absorption of dietary iron, although population-based data showing its ef®cacy in reducing anaemia or iron de®ciency are lacking. Vitamin E supplementation given to preterm infants has not reduced the severity of the anaemia of prematurity. Vitamin B 6 effectively treats sideroblastic anaemia. Multivitamin supplementation may raise haemoglobin (Hb) concentration, but few studies have isolated the effect of multivitamins from iron on haematological status. Conclusions: In general, the public health impact of vitamin supplementation in controlling anaemia is not clear. Neither are the complex interactions involving multiple vitamins in haematopoiesis suf®ciently understood to explain the observed variability in haematological responses to vitamins by age, population, vitamin mixture and dosages. Further research is needed to understand the roles of individual and combined vitamin de®ciencies on anaemia to design appropriate micronutrient interventions to prevent anaemia.

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Section: Folatementioning

confidence: 99%

The role of vitamins in the prevention and control of anaemia

Fishman

Christian

West

2000

Public Health Nutr.

265

208

View full text Add to dashboard Cite

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“…Estos niveles caen progresivamente despues del parto, llegando a los 6 meses de 2 a 3 ng/ml en el suero y de 100 a 180 ng/ml en los gl6bulos rojos. Esta baja es mas acentuada en los reci£n nacidos de pretermino, pues sus depositos hepaticos son menores (2,3,8). Ello lleva a que los niveles de folato serico y en globulos rojos lleguen a ser deficitarios entre uno a tres meses de edad con una frecuencia de 28% en los prematuros y de 68% entre aquellos con menos de 1.700 grs.…”

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“…de peso al nacer (5). La alta frecuencia de deficit de acido folico no tiene sin embargo una traduccion clinica importante, con side ran dose mas bien como un deficit subclinico que ante circunstancias especiales como infecciones o restricciones dieteticas pudiera llevar a alteraciones hematoldgicas o a una detencion en la curva de crecimiento (2,5,7,12).…”

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“…Se han hecho diversos estudios dando acido folico como suplemento dietetico intentando asi prevenir la anemia de las 6 a 8 semanas de vida. En todos estos estudios se ha conseguido elevar las concentraciones de acido f61ico en el suero y en globulos rojos (2,6,13), pero los resultados en cuanto a prevenir la anemia o a mejorar la curva de peso son contradictorios (2,6,10,13).…”

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“…Los resultados de esta serie confirman que el suplemento de acido folico en la dieta de los recien nacidos de pretermino no mejora su curva ponderal aun cuando experimentalmente el deficit de acido folico interfiere en el crecimiento (2). Puede en efecto verse en el grafico N?…”

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