Response of Maize Planted after Two Legumes to Four Rates of Phosphate Rock

Odedina, Joy Nwakaego; Odedina, S. A.; Fabunmi, T. O.; Adigbo, Sunday Ojo

doi:10.9734/ajea/2015/18454

Cited by 1 publication

(1 citation statement)

References 15 publications

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“…Prostate cancer was chosen as a tumor model to demonstrate proof of principle and because of the clinical significance. 19,20 As a model system, we chose the human prostate cancer cell lines, PC-3, which expresses high levels of integrin α 2 β 1 . 21 Expression of integrin α 2 β 1 has been linked to a worse prognosis, thus making it an important diagnostic marker and therapeutic target.…”

Section: Introductionmentioning

confidence: 99%

Physalis Mottle Virus-like Nanoparticles for Targeted Cancer Imaging

Masarapu

et al. 2019

ACS Appl. Mater. Interfaces

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One of the greatest challenges in nanomedicine is the low efficiency with which nanoparticles are delivered to lesions such as tumors in vivo. Here, we show that Physalis mottle virus (PhMV)-like nanoparticles can be developed as bimodal contrast agents to achieve long circulation, specific targeting capability, and efficient delivery to tumors in vivo. The self-assembling coat protein nanostructure offers various opportunities to modify the internal and external surfaces separately. After loading the internal cavity of the particles with the fluorescent dye Cy5.5 and paramagnetic Gd(III) complexes, we modified the outer surface by PEGylation and conjugation with targeting peptides. Using this combined approach, we were able to monitor a human prostate tumor model for up to 10 days by near-infrared fluorescence and magnetic resonance imaging, with up to 6% of the injection dose remaining. Our results show that PhMV-like nanoparticles provide a promising and innovative platform for the development of next-generation diagnostic and therapeutic agents.

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Section: Introductionmentioning

confidence: 99%

Physalis Mottle Virus-like Nanoparticles for Targeted Cancer Imaging

Masarapu

et al. 2019

ACS Appl. Mater. Interfaces

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Response of Maize Planted after Two Legumes to Four Rates of Phosphate Rock

Cited by 1 publication

References 15 publications

Physalis Mottle Virus-like Nanoparticles for Targeted Cancer Imaging

Physalis Mottle Virus-like Nanoparticles for Targeted Cancer Imaging

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