2019
DOI: 10.3389/fnins.2019.00324
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Response of Mouse Visual Cortical Neurons to Electric Stimulation of the Retina

Abstract: Retinal prostheses strive to restore vision to the blind by electrically stimulating the neurons that survive the disease process. Clinical effectiveness has been limited however, and much ongoing effort is devoted toward the development of improved stimulation strategies, especially ones that better replicate physiological patterns of neural signaling. Here, to better understand the potential effectiveness of different stimulation strategies, we explore the responses of neurons in the primary visual cortex to… Show more

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Cited by 17 publications
(10 citation statements)
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References 78 publications
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“…5 E , vertical red dashed line), and this value served as our boundary to split cells into NS and BS cells. In accordance with previous reports (e.g., Niell and Stryker, 2008 ; Bigelow et al, 2019 ; Ryu et al, 2019 ), the spontaneous FR of NS cells was typically faster than BS cells (10.2 ± 8.8 Hz vs 2.3 ± 2.9 Hz, Mann–Whitney U test: p < 0.001).…”
Section: Methodssupporting
confidence: 92%
“…5 E , vertical red dashed line), and this value served as our boundary to split cells into NS and BS cells. In accordance with previous reports (e.g., Niell and Stryker, 2008 ; Bigelow et al, 2019 ; Ryu et al, 2019 ), the spontaneous FR of NS cells was typically faster than BS cells (10.2 ± 8.8 Hz vs 2.3 ± 2.9 Hz, Mann–Whitney U test: p < 0.001).…”
Section: Methodssupporting
confidence: 92%
“…Further studies to understand why different neurons have preferred temporal profiles can shed light on the effects of frequency modulation. Biomimetic amplitude modulation, which consistently evoked distinct onset and offset transients, should more consistently evoke neural transients similar to those present in recorded neural data [16],[18].…”
Section: Discussionmentioning
confidence: 84%
“…Biomimetic ICMS that mimics cortical activity can potentially improve evoked percepts and efficacy [12]- [15]. In sensory cortices, neurons respond strongly to the onset and offset of sensory input with modest firing in between [16]- [18]. To mimic these strong transients, amplitude or frequency of ICMS can be elevated during onset and offset.…”
Section: Introductionmentioning
confidence: 99%
“…The depth along the recording probe of each neuron was used to sort the neurons into their estimated cortical layer. Instantaneous firing rate was measured to check whether highest firing rates were found in L5 as expected from literature (Narayanan et al, 2017a;Ryu et al, 2019). Correlation in each layer were then compared using the same process and metric as stated previously.…”
Section: Electrophysiological Preprocessing and Analysismentioning
confidence: 99%