Response of Myocardial Fine Structure to Cardiac Arrest and Hypothermia

Electron microscopic observations in alcoholic heart disease.

“…The latter showed loss of muscle elements and mitochondria with replacement by dense scar tissue and fat. Mitochondrial swelling, damaged and destroyed cristz, and even round dense bodies have been described in hypoxic dog hearts (Burdette and Ashford, 1963). Whether the mitochondria are actually increased in number or only apparently so as a result of occupying space formerly occupied by contractile elements cannot yet be determined.…”

Myocardial Ultrastructure in Acute and Chronic Hypoxia

“…Edema was found in arrested hearts perfused with whole blood for 100 min at 37 °C [13]; hypoxia (clamping of arterial supply for 30 min increased this edema and also resulted in mitochondrial and nuclear damage. T a h er i et al [79] observed that perfusion of canine hearts for 24 h under deep hypothermia, (4 °C) with and without hyperbaric oxygenation, led to edema, extensive cellular damage and poor contractile function.…”

Ultrastructural Aspects of Human Myocardial Capillaries During Open Heart Surgery

“…Recovery of myocardial lesions were experimentally observed after 30 min of ischaemia followed by 30 min of perfusion [1,6,7]. Failure of these findings in our study can be due to the short time of coronary perfusion.…”