Response of patients with IgM and IgA-associated peripheral polyneuropathies to ?off-line? immunoadsorption treatment using the Prosorba� protein A column

Niemierko, Ewa; Weinstein, Robert S.

doi:10.1002/(sici)1098-1101(1999)14:4<159::aid-jca1>3.0.co;2-q

Cited by 7 publications

(1 citation statement)

References 19 publications

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“…Both patients suffered from IgG paraproteins. Niemienko and Weinstein (51) later reported successful treatment of sensory demyelinating polyneuropathies in two patients, one with an IgM paraprotein and the other with an IgA paraprotein. Patients were treated six times over a 2 week period.…”

Section: Other Experimental Applications Of Prosorba In Autoimmune DImentioning

confidence: 99%

Correcting Immune Imbalance: The Use of Prosorba Column Treatment for Immune Disorders

Levy¹,

Degani²

2003

Ther Apher Dial

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The treatment of selected refractory autoimmune diseases has been complemented by the use of Protein A (Prosorba column) immunoadsorption. US Food and Drug Administration-approved clinical applications include idiopathic thrombocytopenia purpura (ITP) and rheumatoid arthritis (RA). Other common off label uses include thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). Less common experimental uses in diseases in which efficacy has been reported include autoimmune CNS syndromes, peripheral neuropathies, autoimmune pancytopenia, hemolytic anemia and solid organ transplant rejection. Prosorba column treatment is generally well tolerated but a small proportion of treated patients experience chills, fever, tremor, hypotension and rash. The mechanism of action suggested for the efficacy of the column is the restoration of normal immune balance and normal tolerance. Observations in ITP has suggested that column treatment stimulates a rise in anti-idiotype antibody directed against antiplatelet antibodies, effecting a decrease in pathogenic antiplatelet antibodies and immune complexes.

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Section: Other Experimental Applications Of Prosorba In Autoimmune DImentioning

confidence: 99%

Correcting Immune Imbalance: The Use of Prosorba Column Treatment for Immune Disorders

Levy¹,

Degani²

2003

Ther Apher Dial

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Therapeutic apheresis in neurological disorders

Weinstein

2000

J. Clin. Apheresis

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Immunotherapy for IgM anti-myelin-associated glycoprotein paraprotein-associated peripheral neuropathies

Lunn¹,

Nobile‐Orazio²

2006

Cochrane Database of Systematic Reviews

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Response of patients with IgM and IgA-associated peripheral polyneuropathies to ?off-line? immunoadsorption treatment using the Prosorba� protein A column

Cited by 7 publications

References 19 publications

Correcting Immune Imbalance: The Use of Prosorba Column Treatment for Immune Disorders

Correcting Immune Imbalance: The Use of Prosorba Column Treatment for Immune Disorders

Therapeutic apheresis in neurological disorders

Immunotherapy for IgM anti-myelin-associated glycoprotein paraprotein-associated peripheral neuropathies

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