Response of peripheral nerve to He‐Ne laser: Experimental studies

Rochkind, S.; Nissan, Moshe; Barr-Nea, L.; Razon, N.; Schwartz, Michal; Bartal, A.

doi:10.1002/lsm.1900070512

Cited by 96 publications

(63 citation statements)

References 6 publications

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“…Laser phototherapy significantly improves recovery of the injured peripheral nerve, 1,5,14,20,24 and in addition, decreases posttraumatic retrograde degeneration of the neurons in the corresponding segments of the spinal cord. 15 Our previous studies investigating the effects of low-power laser irradiation on an injured peripheral nerve in rats have found that it provides: 1) immediate protective effects that increase the functional activity of the injured peripheral nerve; 21 2) maintenance of functional activity of the injured nerve over time; 14 3) a decrease or prevention of scar tissue formation at the site of injury (Fig.…”

Section: Experimental Peripheral Nerve Crush Injurymentioning

confidence: 98%

Phototherapy in peripheral nerve regeneration: From basic science to clinical study

Rochkind

2009

FOC

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Object This review summarizes the continuous study of low-power laser radiation treatment of a severely injured peripheral nerve. Laser phototherapy was applied as a supportive factor for accelerating and enhancing axonal growth and regeneration after injury or a reconstructive peripheral nerve procedure. In nerve cell cultures, laser phototherapy was used to stimulate activation of nerve cells. Methods Low-power laser radiation was used for treatment of peripheral nerve injury using a rat sciatic nerve model after crush injury, neurorrhaphy, or neurotube reconstruction. Nerve cell growth and axonal sprouting were investigated using laser phototherapy on embryonic rat brain cultures. The outcome in animal studies facilitated a clinical double-blind, placebo-controlled, randomized study that measured the effectiveness of 780-nm laser phototherapy on patients suffering from incomplete peripheral nerve injuries for 6 months to several years. Results Animal studies showed that laser phototherapy has an immediate protective effect, maintains functional activity of the injured nerve, decreases scar tissue formation at the injury site, decreases degeneration in corresponding motor neurons of the spinal cord, and significantly increases axonal growth and myelinization. In cell cultures, laser irradiation accelerates migration, nerve cell growth, and fiber sprouting. A pilot clinical double-blind, placebocontrolled, randomized study showed that in patients with incomplete long-term peripheral nerve injury, 780-nm laser radiation can progressively improve peripheral nerve function, which leads to significant functional recovery. Conclusions Using 780-nm laser phototherapy accelerates and enhances axonal growth and regeneration after injury or a reconstructive peripheral nerve procedure. Laser activation of nerve cells, their growth, and axonal sprouting can be considered as potential treatment of neuronal injury. Animal and clinical studies show the promoting action of phototherapy on peripheral nerve regeneration, making it possible to suggest that the time for broader clinical trials has arrived.

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Section: Experimental Peripheral Nerve Crush Injurymentioning

confidence: 98%

Phototherapy in peripheral nerve regeneration: From basic science to clinical study

Rochkind

2009

FOC

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“…The mechanism involved is mostly unknown. According to physiological experiments, He-Ne laser irradiation does not affect peripheral Ad-or Cfiber nociceptors (Jarvis et al 1990), but does affect electric activity (action potential), which in the healthy nerve increased by 33% following a single transcutaneous irradiation (Rochkind et al 1986(Rochkind et al , 1987. This was found to be a long-lasting effect, inducing an increase in the size of nerves action potential for more than eight months after cessation of irradiation (Rochkind et al 1986).…”

Section: Investigatorsmentioning

confidence: 99%

Treatment of dentine hypersensitivity by lasers: a review

Kimura

Wilder‐Smith

Yonaga

et al. 2000

J Clinic Periodontology

289

224

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Background, aims: Since the development of the ruby laser by Maiman in 1960, a variety of papers on potential applications for lasers in dentistry have been published. The purpose of this paper is to summarise laser applications for the treatment of dentine hypersensitivity. The effects of laser on pulp tissue and problems on laser treatment are also reviewed. This article reviews the role of lasers for the treatment of dentine hypersensitivity since 1985, summarises many research reports from the last decade, and surmises what the future may hold for lasers in this treatment. Method: To date, 4 kinds of lasers have been used for the treatment of dentine hypersensitivity, and the effectiveness ranged from 5.2 to 100%, which was dependent on the laser type and parameters used. The mechanism involved in laser treatment of dentine hypersensitivity are relatively unknown. Results: These require clarification to result in safely effective treatment optimization. In general, the efficiency for the treatment of dentine hypersensitivity using lasers is higher than other methods, but in severe cases, it is less effective. Conclusion: It is necessary to consider the severity of dentine hypersensitivity before laser use.

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“…Following 20 days of 17-mM' He-Ne laser irradiation, they reported a significantly higher (P < .001) frequency of evoked action potentials in the treated limb. An effect in the contralateral control limb was also observed, and treatment started later than 4 days was not found to be as effective as that begun immediately following injury (9,10). In 1989, they reported the outcome of a longterm studv of He-Ne irradiation applied 7 minutes daily for 20 days.…”

Section: Of the Crushed Peroneal Nervementioning

confidence: 99%