Response of preantral follicles exposed to quinoxaline: A new compound with anticancer potential

A possible potential COVID-19 drug candidate: Diethyl 2-(2-(2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetyl)hydrazono)malonate: Docking of disordered independent molecules of a novel crystal structure, HSA/DFT/XRD and cytotoxicity

“…Currently, several molecules are being tested for their efficiency on COVID-19 disease, some of which have reached clinical trials, while others are still in the preclinical phase ( Sanders et al, 2020 , Luo et al, 2020 , Colaneri et al, 2020 , Quartuccio et al, 2020 , Campochiaro et al, 2020 ). Quinoxaline as a wonder nucleus in the fused systems of nitrogen-containing heterocycles, is important nitrogenous hetero compound due to their extensive properties, ( Ramli and Essassi, 2015 , Ramli et al, 2014 , Zarrok et al, 2012 , Tazouti et al, 2016 , El Aoufir et al, 2016 , Laabaissi et al, 2019 ) and shows a variety of activities in the medical field, including analgesic ( Dewangan et al, 2018 ), anti-inflammatory ( Shen et al, 2020 )anti-tubercular ( Srinivasarao et al, 2020 ), anti-bacterial ( Patel et al, 2019 ), bacteriocides ( Thakuria and Das, 2006 ), anti-HIV ( Patel et al, 2016 ), anti-diabetic ( Kulkarni et al, 2012 ), anti-oxydant ( Missioui et al, 2021 ) and anti-cancer ( Guerreiro et al, 2020 , Abad et al, 2021 ) agents. Malonate-based compounds have aroused increasing attention because of their important pharmacological activities, such as decreased blood glucose ( Shinkai et al, 1998 ) anti-HIV ( Serafin et al, 2011 ) anticancer ( Xing et al, 2012 ) anti-inflammatory ( Kim et al, 2001 ) antioxidative ( Saranya et al, 2013 ) and antiviral ( Xiao et al, 2014 ) activities.…”

Synthesis and Cytotoxic Activity of Arenecarbaldehyde 2-Pyridinylhydrazone Derivatives

“…[12] The hydrazonyl functional group, CH=N-NH, readily formed from hydrazines and arenecarbaldehydes, is found in many compounds with a wide range of pharmacological activities, including antibacterial, antifungal, anticonvulsant, anti-inflammatory, antimalarial, antitubercular, and anti-cancer activities. [13][14][15][16][17][18][19][20][21][22] In our earlier studies on anticancer activities of heteroaromatic compounds, we identified a series of hydrazonyl compounds with promising antitumoral activities based on the isonicotinoyl, [23] quinolinyl, [24] and quinoxalinyl [25][26][27] frameworks. In our continuing search for new potent and safe antineoplastic agents and on the basis of the results of these previous studies, we have investigated the potential of pyridin-2-yl-hydrazones, arene-CH=N-NH-pyridin-2-yl derivatives as anticancer agents.…”