Response of regional brain glutamate transaminases of rat to aluminum in protein malnutrition

Abstract

Background: The mechanism of aluminum-induced neurotoxicity is not clear. The involvement of glutamate in the aluminium-induced neurocomplications has been suggested. Brain glutamate levels also found to be altered in protein malnutrition. Alterations in glutamate levels as well as glutamate-α-decarboxylase in different regions of rat brain has been reported in response to aluminum exposure. Thus the study of glutamate metabolising enzymes in different brain regions of rats maintained on either normal or restricted protein diet may be of importance for understanding the neurotoxicity properties of aluminium.

Does neurotransmission impairment accompany aluminium neurotoxicity?

“…The complexity of compartmentation of glutamate metabolism within nerve terminals is not fully understood [103]. Yet, it is plausible to assume that the reported inhibition by aluminium of glutamate dehydrogenase [102] and aspartate transaminase (EC 2.6.1.1) [104] could cause the compromise the synaptic function.…”

Targeting Glutamine Addiction in Gliomas

“…Aminotransferases synthetize αKG without releasing ammonia. In the CNS, both alanine aminotransferase (glutamate-pyruvate transferase; GPT) and aspartate aminotransferase (glutamate-oxoloacetate transaminase; GOT) operate [33].…”

Potential health concerns of trace elements and mineral content in commonly consumed greenhouse vegetables in Isfahan, Iran

“…It should be noted that in many of the analytical methods used by the scientists to determine the levels of Al in the environment and foods, a distinct toxic level for this element has not been determined and only a total amount in the samples presented. [ 10 ]…”

“…In this regard, many studies have been done to quantify the trace elements and mineral contents of various vegetables and fruits. [ 3 8 9 10 11 ] However, according to the best of our knowledge, there is no report on greenhouses crops in Isfahan, Iran, with the methodology and analysis described here.…”