Response of Renal Allograft Recipients to Pneumococcal Vaccine

Abstract

Antibody responses to pneumococcal polysaccharide vaccine were compared in a control group of 17 normal adults and in a group of 27 adult patients with stable renal function (serum creatinine 0.8--2.1 mg/dl) seven months to nine years following renal transplantation. Using the indirect hemagglutination technique, antibody titers to 13 of the 14 capsular antigens contained in the vaccine were determined for each patient just prior to and again three weeks following immunization. There was no significant difference between the two groups in the proportion of patients responding with a fourfold rise in titer to 12 of the 13 antigens tested. The response rate to antigen type 3 was reduced in the transplant group (p less than 0.05). Mean fold increase in indirect hemagglutination titers was likewise determined for each antigen, and a reduced response in the transplant group was noted only to antigen type 23 (p = 0.037). Immunosuppressed renal allograft recipients appear capable of mounting a nearly normal antibody response to pneumococcal vaccine.

Randomized, Double‐Blind, Controlled Trial of Pneumococcal Vaccination in Renal Transplant Recipients

“…However, in at University of California, Santa Cruz on April 5, 2015 http://jid.oxfordjournals.org/ Downloaded from contrast, other studies have shown relatively good responses to the polysaccharide vaccine. Cosio et al [15] showed that 80% of allograft recipients had a 2-fold increase in antibody concentration after vaccination, and Silberman et al [16] demonstrated that renal transplant recipients with stable allograft function are able to mount an antibody response comparable to that of healthy control subjects. Although these studies were done prior to the era of modern immunosuppression, a more recent noncomparative study did find a significant increase in antibody titers after polysaccharide vaccination in 20 of 21 renal transplant recipients [17].…”

The Effect of Sirolimus Therapy on Vaccine Responses in Transplant Recipients

“…A number of studies have measured antibody responses to vaccination in solid organ transplant recipients. Early studies of recipients maintained on prednisolone and azathioprine found no difference in antibody titers compared with healthy controls (5,6). Responses to influenza vaccination are reduced by ciclosporin (a calcineurin inhibitor [CNI]) and further dampened by subsequent addition of mycophenolate mofetil (MMF) (7,8).…”

Assessment of humoral and cell-mediated immune response to measles‐mumps‐rubella vaccine viruses among patients with asthma

“…In our study cohort, only one subject was on inhaled corticosteroids within 30 days before the determination of the immune response and, thus, these findings are unlikely to be explained by the influence of corticosteroids, although corticosteroid has not been associated with poorer humoral or cell-mediated responses (CMI) to vaccines. 17,27,28 …”