1989
DOI: 10.1159/000181120
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Response of Serine Antiproteases to Growth Hormone Therapy in Growth Hormone Deficient Children

Abstract: Growth hormone regulates the hepatic mRNA levels of α1-antitrypsin and two contrapsin-like mRNAs in the rat. To determine whether growth hormone regulates similar serine protease inhibitors in humans, we measured serum α1-antitrypsin, α1-antichymotrypsin, and antithrombin III by radioimmunodiffusion in 16 growth hormone deficient children before and after growth hormone therapy. Of the 19 determinations made, 17/19 showed an increase in α1-antirypsin after administra… Show more

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Cited by 3 publications
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“…It is also an acute‐phase protein that is secreted in large amounts by the liver in response to acute infection or injury 27. AAT expression in the liver responds to GH in both rats and humans 28, 29, and GH‐deficiency is often associated with deficiency in AAT 30. The one isoform of AAT that significantly increased at day 8 with rhGH treatment is consistent with these findings.…”
Section: Discussionmentioning
confidence: 99%
“…It is also an acute‐phase protein that is secreted in large amounts by the liver in response to acute infection or injury 27. AAT expression in the liver responds to GH in both rats and humans 28, 29, and GH‐deficiency is often associated with deficiency in AAT 30. The one isoform of AAT that significantly increased at day 8 with rhGH treatment is consistent with these findings.…”
Section: Discussionmentioning
confidence: 99%