Response of SI cortex to ipsilateral, contralateral and bilateral flutter stimulation in the cat

Tommerdahl, Mark; Simons, Stephen B.; Chiu, Joannellyn S; Favorov, Oleg V.; Whitsel, B. L.

doi:10.1186/1471-2202-6-29

Cited by 20 publications

(6 citation statements)

References 35 publications

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“…An early animal study found that SII receives substantial inputs from topographically appropriate regions within the ipsilateral ventrobasal nucleus and from the ipsilateral posterior group (Carvell and Simons, 1987), which indicated that SII in mice may complement the function of SI by helping to define the overall sensory context in which detailed tactile discriminations are made. Our findings suggested that the right SII was involved in both low and high velocities and might play an important role in discriminating the velocity of orofacial tactile stimuli (Carvell and Simons, 1987;Tommerdahl et al, 2005a). Moreover, there was no statistically significant difference in connection strength for the 25 cm/s vs "All ON" conditions.…”

Section: Effects Of Velocitymentioning

confidence: 58%

Functional Connectivity Evoked by Orofacial Tactile Perception of Velocity

et al. 2020

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The cortical representations of orofacial pneumotactile stimulation involve complex neuronal networks, which are still unknown. This study aims to identify the characteristics of functional connectivity (FC) evoked by three different saltatory velocities over the perioral and buccal surface of the lower face using functional magnetic resonance imaging in twenty neurotypical adults. Our results showed a velocity of 25 cm/s evoked stronger connection strength between the right dorsolateral prefrontal cortex and the right thalamus than a velocity of 5 cm/s. The decreased FC between the right secondary somatosensory cortex and right posterior parietal cortex for 5-cm/s velocity versus all three velocities delivered simultaneously ("All ON") and the increased FC between the right thalamus and bilateral secondary somatosensory cortex for 65 cm/s vs "All ON" indicated that the right secondary somatosensory cortex might play a role in the orofacial tactile perception of velocity. Our results have also shown different patterns of FC for each seed (bilateral primary and secondary somatosensory cortex) at various velocity contrasts (5 vs 25 cm/s, 5 vs 65 cm/s, and 25 vs 65 cm/s). The similarities and differences of FC among three velocities shed light on the neuronal networks encoding the orofacial tactile perception of velocity.

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Section: Effects Of Velocitymentioning

confidence: 58%

Functional Connectivity Evoked by Orofacial Tactile Perception of Velocity

et al. 2020

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“…In humans, neuroimaging studies using fMRI and MEG have provided evidence of bilateral interactions in SI (Hlushchuk & Hari, 2006;Kakigi, 1986;Kakigi & Jones, 1985;Sutherland & Tang, 2006;Tan et al, 2004;Tommerdahl, Simons, Chiu, Favorov, & Whitsel, 2006). In a recent study, we examined the contribution of SI and SII to the spatial coding of touch at the fingers of the same or different hands, taking advantage of the fMRI adaptation paradigm (Tamè et al, 2012).…”

Section: Direct Evidence For Bilateral Interactions In Si: Brain Imagmentioning

confidence: 99%

“…A second possibility (SI-SI transcallosal projections) is that SI receives ipsilateral somatosensory inputs from contralateral SI, via transcallosal fibres (Allison, McCarthy, Wood, Williamson, & Spencer, 1989;Caminiti et al, 2013;Fabri et al, 2001;Fabri et al, 2005;Fling, Benson, & Seidler, 2013). Finally, a third possibility (SII-SII or SII-SI transcallosal projections) is that cortico-cortical modulations of SI could also emerge via transcallosal connections between homologous SII regions or from heterotopic SII and SI regions (Schnitzler, Salmelin, Salenius, Jousmäki, & Hari, 1995;Tommerdahl et al, 2006).…”

Section: Anatomical Pathways Serving Bilateral Integration In Simentioning

confidence: 99%

Bilateral representations of touch in the primary somatosensory cortex

Tamè

Braun

Holmes

et al. 2016

Cognitive Neuropsychology

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According to current textbook knowledge, the primary somatosensory cortex (SI) supports unilateral tactile representations, whereas structures beyond SI, in particular the secondary somatosensory cortex (SII), support bilateral tactile representations. However, dexterous and well-coordinated bimanual motor tasks require early integration of bilateral tactile information. Sequential processing, first of unilateral and subsequently of bilateral sensory information, might not be sufficient to accomplish these tasks. This view of sequential processing in the somatosensory system might therefore be questioned, at least for demanding bimanual tasks. Evidence from the last 15 years is forcing a revision of this textbook notion. Studies in animals and humans indicate that SI is more than a simple relay for unilateral sensory information and, together with SII, contributes to the integration of somatosensory inputs from both sides of the body. Here, we review a series of recent works from our own and other laboratories in favour of interactions between tactile stimuli on the two sides of the body at early stages of processing. We focus on tactile processing, although a similar logic may also apply to other aspects of somatosensation. We begin by describing the basic anatomy and physiology of interhemispheric transfer, drawing on neurophysiological studies in animals and behavioural studies in humans that showed tactile interactions between body sides, both in healthy and in brain-damaged individuals. Then we describe the neural substrates of bilateral interactions in somatosensation as revealed by neurophysiological work in animals and neuroimaging studies in humans (i.e., functional magnetic resonance imaging, magnetoencephalography, and transcranial magnetic stimulation). Finally, we conclude with considerations on the dilemma of how efficiently integrating bilateral sensory information at early processing stages can coexist with more lateralized representations of somatosensory input, in the context of motor control.

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“…Most studies of somatosensation concentrate on a single cerebral hemisphere and examine the neocortical representations of tactile signals arising from the opposite, or contralateral, side of the body. However, across species, ipsilateral tactile stimuli have also been shown to evoke changes in population activity of primary (S1) and secondary (S2) somatosensory cortex (Pidoux and Verley, 1979;Tommerdahl et al, 2005;Hlushchuk and Hari, 2006;Lipton et al, 2006;Ferezou et al, 2007;Eickhoff et al, 2008;Plomp et al, 2017;Song et al, 2018), mainly mediated by corticocortical projections via the corpus callosum (Pidoux and Verley, 1979;Picard et al, 1990;Fabri et al, 1999). Yet, surprisingly little is known about the cellular-level specificity of ipsilateral stimulus-evoked activity in S1 and S2, and about its potential role in the neocortical encoding of tactile information during awake somatosensation.…”

Section: Introductionmentioning

confidence: 99%

Ipsilateral Stimulus Encoding in Primary and Secondary Somatosensory Cortex of Awake Mice

Pala

Stanley

2022

J. Neurosci.

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Lateralization is a hallmark of somatosensory processing in the mammalian brain. However, in addition to their contralateral representation, unilateral tactile stimuli also modulate neuronal activity in somatosensory cortices of the ipsilateral hemisphere. The cellular organization and functional role of these ipsilateral stimulus responses in awake somatosensory cortices, especially regarding stimulus coding, are unknown. Here, we targeted silicon probe recordings to the vibrissa region of primary (S1) and secondary (S2) somatosensory cortex of awake head-fixed mice of either sex while delivering ipsilateral and contralateral whisker stimuli. Ipsilateral stimuli drove larger and more reliable responses in S2 than in S1, and activated a larger fraction of stimulus-responsive neurons. Ipsilateral stimulus-responsive neurons were rare in layer 4 of S1, but were located in equal proportion across all layers in S2. Linear classifier analyses further revealed that decoding of the ipsilateral stimulus was more accurate in S2 than S1, whereas S1 decoded contralateral stimuli most accurately. These results reveal substantial encoding of ipsilateral stimuli in S1 and especially S2, consistent with the hypothesis that higher cortical areas may integrate tactile inputs across larger portions of space, spanning both sides of the body.

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Response of SI cortex to ipsilateral, contralateral and bilateral flutter stimulation in the cat

Cited by 20 publications

References 35 publications

Functional Connectivity Evoked by Orofacial Tactile Perception of Velocity

Functional Connectivity Evoked by Orofacial Tactile Perception of Velocity

Bilateral representations of touch in the primary somatosensory cortex

Ipsilateral Stimulus Encoding in Primary and Secondary Somatosensory Cortex of Awake Mice

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