Response of the Mouse Femoral Muscle to an Implant of a Composite of Bone Morphogenetic Protein and Plaster of Paris

Yamazaki, Yasuharu; Oida, Shinichiro; Akimoto, Yasushi; Shioda, Shigetoshi

doi:10.1097/00003086-198809000-00043

Cited by 73 publications

(39 citation statements)

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“…Several authors describe CaSO 4 as a carrier of bone morphogenetic protein (BMP) (29)(30)(31) as well as antibiotics (32)(33)(34)(35). Bai et al have tested BMP-loaded calcium sulfate in a clinical trial with 16 patients and successfully induced bone healing after prior nonunion of fractures (29).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Formulations of Absorbable Bone Substitute Materials as Drug Carriers Based on Calcium Sulfate

Pförringer

Obermeier

Kiokekli

et al. 2016

Antimicrob Agents Chemother

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c Substitution of bones is a well-established, necessary procedure to treat bone defects in trauma and orthopedic surgeries. For prevention or treatment of perioperative infection, the implantation of resorbable bone substitute materials carrying antibiotics is a necessary treatment. In this study, we investigated the newly formulated calcium-based resorbable bone substitute materials containing either gentamicin (CaSO 4 -G [Herafill-G]), vancomycin (CaSO 4 -V), or tobramycin (Osteoset). We characterized the released antibiotic concentration per unit. Bone substitute materials were implanted in bones of rabbits via a standardized surgical procedure. Clinical parameters and levels of the antibiotic-releasing materials in serum were determined. Local concentrations of antibiotics were measured using antimicrobial tests of bone tissue. Aminoglycoside release kinetics in vitro per square millimeter of bead surface showed the most prolonged release for gentamicin, followed by vancomycin and, with the fastest release, tobramycin. In vivo level in serum detected over 28 days was highest for gentamicin at 0.42 g/ml, followed by vancomycin at 0.11 g/ml and tobramycin at 0.04 g/ml. The clinical parameters indicated high biocompatibility for materials used. None of the rabbits subjected to the procedure showed any adverse reaction. The highest availability of antibiotics at 14.8 g/g on day 1 in the cortical tibia ex vivo was demonstrated for gentamicin, decreasing within 14 days. In the medulla, vancomycin showed a high level at 444 g/g on day 1, decreasing continuously over 14 days, whereas gentamicin decreased faster within the initial 3 days. The compared antibiotic formulations varied significantly in release kinetics in serum as well as locally in medulla and cortex.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Formulations of Absorbable Bone Substitute Materials as Drug Carriers Based on Calcium Sulfate

Pförringer

Obermeier

Kiokekli

et al. 2016

Antimicrob Agents Chemother

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“…19 As a material for repair of bone defects, BMP depends on a suitable framework for mechanical support and release. 20 Although many biomaterials have been studied, such as hydroxyapatite (HA), 21 ␤-tricalcium phosphate (ß-TCP), 22 polylactide and polyglycolide (PLA/PGA) 23 and plaster of Paris (POP), 24 most are difficult to absorb and remain in the body for a long time, possibly several years. 25,26 By contrast, the treated cancellous bone used in our study has several advantages.…”

Section: Discussionmentioning

confidence: 99%

The treatment of osteomyelitis with gentamicin-reconstituted bone xenograft-composite

2001

The Journal of Bone and Joint Surgery. British volume

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W e have developed a new drug-delivery system using reconstituted bone xenograft to treat chronic osteomyelitis. This material, which has the capabilities of osteoinduction and osteoconduction, was supplemented with up to 2000 times the minimum inhibitory concentration of gentamicin against Staphylococcus aureus to prepare a gentamicin-reconstituted bone xenograft-composite (G-RBX-C). In a rabbit model, we evaluated the release of gentamicin from this composite in vivo, its capability for induction of ectopic bone and the repair of segmental defects of the radius.There was a high level of concentration of antibiotics, which was sustained for at least ten days. In the study of induction of ectopic bone, there was abundant woven bone in the G-RBX-C group two weeks after operation. At 16 weeks after implantation of G-RBX-C the radial defects had been repaired, with the formation of lamellar bone and recanalisation of the marrow cavity. Our findings suggest that G-RBX-C may be useful in the treatment of chronic osteomyelitis.

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“…Several materials, such as p-tricalcium phosphate (Urist et al 1984, Urist et al 1987, matrix gammacarboxyglutamic acid-rich protein (Sato and Urist 1985), collagen (Deathergate and Miller 1987), fibrin sealant (Schwarz et al 1989), plaster of Paris (Yamazaki et al 1988), copolymer of polylactidepolyglycolide (Schmitz and Hollinger 1988), polylactic acid (Lovell et al 1989), and polyanhydride (Lucas et al 1990), have been investigated as biodegradable vehicles.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, in some studies the osteoinductor alone has not been evaluated (Deathergate and Miller 1987. Urist et al 1987, Lovell et al 1989, or it has been implanted in gelatin capsules (Urist et al 1984, Yamazaki et al 1988.…”

Section: Discussionmentioning

confidence: 99%

Bone induction by composite of bioerodible polyorthoester and demineralized bone matrix in rats

Pinholt

Solheim

Bang³

et al. 1991

Acta Orthopaedica Scandinavica

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Response of the Mouse Femoral Muscle to an Implant of a Composite of Bone Morphogenetic Protein and Plaster of Paris

Cited by 73 publications

References 0 publications

Antimicrobial Formulations of Absorbable Bone Substitute Materials as Drug Carriers Based on Calcium Sulfate

Antimicrobial Formulations of Absorbable Bone Substitute Materials as Drug Carriers Based on Calcium Sulfate

The treatment of osteomyelitis with gentamicin-reconstituted bone xenograft-composite

Bone induction by composite of bioerodible polyorthoester and demineralized bone matrix in rats

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