Response of the renal vascular bed to acute experimental coronary arterial occlusion

Hanley, Henry G.; Raizner, Albert E.; Inglesby, Thomas V.; Skinner, N.Sheldon

doi:10.1016/0002-9149(72)90498-5

Cited by 31 publications

(18 citation statements)

References 17 publications

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“…The renal nerve responses we observed were quite different from the skeletal muscle vascular responses to coronary occlusion that have been previously reported (2,3,5,13,26 (9,10).…”

Section: Ilycontrasting

confidence: 87%

“…Peterson and Bishop (5) (2). When the appropriate statistical test is applied to their data (analysis of variance) no significant change in renal flow occurred after mercury embolization.…”

Section: Ilymentioning

confidence: 99%

“…Although the hypotension may be due in part to the myocardial ischemia and thus to reduced ventricular function, there is evidence which supports the view that these cardioinhibitory and vasodepressor responses may be in part reflexly mediated via sensory endings in the heart which are activated during myocardial ischemia (2)(3)(4).…”

Section: Introductionmentioning

confidence: 95%

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Reflex Inhibition of Renal Sympathetic Nerve Activity during Myocardial Ischemia Mediated by Left Ventricular Receptors with Vagal Afferents in Dogs

Thames¹,

Abboud²

1979

J. Clin. Invest.

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A B S T R A C T The major goal ofthis investigation was to determine if activation of cardiac receptors during coronary artery occlusion could inhibit efferent renal sympathetic nerve activity. In nine chloralose anesthetized dogs with only carotid (n = 3) or with sinoaortic (n = 6) baroreceptors operative, anterior descending coronary artery (LAD) occlusion resulted in a small decrease in mean arterial pressure (-9.8+±5.1 mm Hg, NS) and in a significant (P < 0.05) increase in renal nerve activity (24.0±4.1%). In these dogs, circumflex coronary artery (Cx) occlusion resulted in greater hypotension (-18

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“…The renal nerve responses we observed were quite different from the skeletal muscle vascular responses to coronary occlusion that have been previously reported (2,3,5,13,26 (9,10).…”

Section: Ilycontrasting

confidence: 87%

“…Peterson and Bishop (5) (2). When the appropriate statistical test is applied to their data (analysis of variance) no significant change in renal flow occurred after mercury embolization.…”

Section: Ilymentioning

confidence: 99%

See 1 more Smart Citation

Reflex Inhibition of Renal Sympathetic Nerve Activity during Myocardial Ischemia Mediated by Left Ventricular Receptors with Vagal Afferents in Dogs

Thames¹,

Abboud²

1979

J. Clin. Invest.

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“…In contrast, when hypotension accompanies acute myocardial infarction, increased stimulation of cardiac vagal afferents may inhibit the arterial baroreflex (45)(46)(47)(48)(49)(50)(51)(52)(53). Impaired vasoconstriction during cardiogenic shock could provide an important mechanism for preventing deleterious elevations in left ventricular afterload.…”

Section: Resultsmentioning

confidence: 99%

Interaction of cardiopulmonary and carotid baroreflex control of vascular resistance in humans.

Victor¹,

Mark²

1985

J. Clin. Invest.

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IntroductionPrevious studies in experimental animals indicate an important inhibitory interaction between cardiopulmonary and arterial baroreflexes. In the dog, for example, cardiopulmonary vagal afferents modulate carotid baroreflex control of vascular resistance. On the other hand, previous studies in human subjects have not produced convincing evidence of a specific interaction between these baroreceptor reflexes. The purpose of this study was to determine whether unloading of cardiopulmonary baroreceptors in humans with nonhypotensive lower body negative pressure selectively augments the reflex vasoconstrictor responses to simulated carotid hypotension produced by neck pressure. In nine healthy subjects, we measured forearm vascular responses with plethysmography during lower body negative pressure alone (cardiopulmonary baroreflex), during neck pressure alone (carotid baroreflex), and during concomitant lower body negative pressure and neck pressure (baroreflex interaction). Lower body negative pressure produced a greater than twofold augmentation of the forearm vasoconstrictor response to neck pressure. This increase in resistance was significantly greater (P < 0.05) than the algebraic sum of the increase in resistance from lower body negative pressure alone plus that from neck pressure alone. In contrast, lower body negative pressure did not potentiate the forearm vasoconstrictor responses either to intra-arterial norepinephrine or to the cold pressor test. Thus, the potentiation of the vasoconstrictor response to neck pressure by lower body negative pressure cannot be explained by augmented reactivity to the neurotransmitter or to a nonspecific augmentation of responses to all reflex vasoconstrictor stimuli.In Hypotension and hypovolemia often occur together in the clinical setting, so the arterial and cardiopulmonary baroreceptors are affected simultaneously (1). In most experimental studies of arterial and cardiopulmonary baroreflexes in humans, however, the reflexes have been activated individually, and the possibility of reflex interaction has received little attention (2). In contrast, an important interaction between high and low pressure baroreceptor reflexes has been demonstrated repeatedly in experimental animals (3-12). In the dog, for example, interruption of cardiopulmonary vagal afferents augments vasoconstrictor responses to carotid hypotension ( 12).Baroreflex interactions are obviously more difficult to study in human subjects than in experimental animals. In previous human studies ofthis reflex interaction, cardiopulmonary baroreflexes have been perturbed with lower body negative pressure (LBNP)' and carotid baroreflexes with neck suction. Using these methods, earlier experiments in this laboratory demonstrated that physiologic variations in central venous pressure do not alter carotid baroreflex control of heart rate in humans (13). Previous studies have also examined vascular responses during combined application of LBNP at -40 mmHg and neck suction (14-16). Because LBNP at -4...

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“…Recently, however, animal studies have shown that renal vasodilatation occurs when systemic hypotension and reduction in cardiac output are produced by experimental coronary artery occlusion (Gorfinkel, Sjidon, Hirsch & Fishman, 1972; Hanley, Rayner, Inglesby & Skinner, 1972;Falicov, Mills & Gabe, 1975). In a preliminary study, Bennett & Keddie (1974) found that after acute myocardial infarction in man, endogenous creatinine clearance was elevated in patients with a moderate degree of left ventricular failure.…”

Section: Introductionmentioning

confidence: 99%

Increased Renal Function in Patients with Acute Left Ventricular Failure: A Possible Homeostatic Mechanism

Bennett¹,

Brooks²,

Keddie³

et al. 1977

Clinical Science

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1.Creatinine clearance and urine excretion have been measured in fifty-five patients admitted with suspected myocardial infarction. Patients were grouped on the basis of their radiological report on the first day, irrespective of their diagnosis. The first group consisted of twenty-six patients with normal chest X-rays, the second group of twenty-two patients with radiological evidence of upper zone vessel dilatation and the third group of seven patients with radiological evidence of pulmonary oedema, who were significantly older.2. The mean creatinine clearance on the first day in patients with upper zone vessel dilatation was significantly higher than the creatinine clearance in patients with normal radiographs. By the third and fourth days the clearances were similar in both groups. The patients with pulmonary oedema had low creatinine clearances on all 4 days.3. Glomerular filtration rate was measured with 51Cr-labelled EDTA on twenty occasions, and the results correlated well with the creatinine clearance values obtained on the same day.4. The mean urine volumes on day 1 (2245 f 286 m1/24 h) and day 2 (2219 f232 d/24 h) in patients with upper zone vessel dilatation who had not received diuretics, were significantly higher (P< 0.01) than the urine volumes on day 1 (1652f 145 d/24 h) and day2(1713 f 118 d/ 24 h) in patients with normal radiographs. All the patients with pulmonary oedema had 43 received diuretics during the study and were therefore excluded from this analysis.5. It is concluded that patients with radiological evidence of upper zone vessel dilatation show an elevation of glomerular filtration rate and an increase in urinary output. It is suggested that these responses are mediated via the stimulation of receptors in the left side of the heart and fulfil a homeostaticfunction, to unload an overdistended heart.

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Response of the renal vascular bed to acute experimental coronary arterial occlusion

Cited by 31 publications

References 17 publications

Reflex Inhibition of Renal Sympathetic Nerve Activity during Myocardial Ischemia Mediated by Left Ventricular Receptors with Vagal Afferents in Dogs

Reflex Inhibition of Renal Sympathetic Nerve Activity during Myocardial Ischemia Mediated by Left Ventricular Receptors with Vagal Afferents in Dogs

Interaction of cardiopulmonary and carotid baroreflex control of vascular resistance in humans.

Increased Renal Function in Patients with Acute Left Ventricular Failure: A Possible Homeostatic Mechanism

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