Response of the Testicular Capsule to Acetylcholine and Noradrenaline

Davis, Joseph R.; Langford, G. A.

doi:10.1038/222386a0

Cited by 40 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported recently that isolated capsular preparations from rat and rabbit contract in response to exogenous noradrenaline, adrenaline and acetylcholine, and on the basis of this evidence it has been proposed that the testicular capsule is autonomically innervated and that it may be physiologi¬ cally important in movement of spermatozoa from the testis (Davis & Langford, 1969;Davis et al, 1970). However, although apparent efferent nerve fibres have been reported to be present in the testicular capsules of bull (Shioda & Nishida, 1966), monkey and man (Baumgarten, 1968), there is no precise evidence regarding the innervation of the capsular smooth muscle.…”

Section: Introductionmentioning

confidence: 99%

The Autonomic Innervation of the Rat Testicular Capsule

Bell¹,

McLean²

1973

Reproduction

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

The Autonomic Innervation of the Rat Testicular Capsule

Bell¹,

McLean²

1973

Reproduction

View full text Add to dashboard Cite

show abstract

“…Previous reports from this laboratory have described the isolation of the testicular capsule of the adult rat and its contractions in response to several pharmacological agents (Davis & Langford, 1969a, b, 1970). In addition, smooth muscle was found to be present in the testicular capsule offering a reasonable anatomical explanation for such drug-induced contractions (Davis, Langford & Kirby, 1970).…”

Section: Introductionmentioning

confidence: 96%

Age-related differences in the response of the isolated testicular capsule of the rat to norepinephrine, acetylcholine and prostaglandins

Davis¹,

Horowitz²

1978

Reproduction

View full text Add to dashboard Cite

The contractile response of the isolated testicular capsule to acetylcholine, norepinephrine and prostaglandins (A-2, E-1 and F-2\g=a\) was related to the age of the rat. Norepinephrine and PGA-2 caused an increased capsular response between 45 and 60 days of age, the time at which spermiogenesis begins. It is suggested that the activity of the testicular capsule is involved in the transport of non-motile spermatozoa from the testis and into the epididymis.

show abstract

“…The mechanism underlying the transport of non-motile spermatozoa from the seminiferous tubules of the testis to the epididymis is not clarified. A number of possible explanations have been offered including ciliary action within the efferent ducts (ZawischOssenitz 1933), active secretion of fluid by the seminiferous tubules (Setchell 1970) and contractile activity of the smooth muscle-like cells of the testicular capsule (Davis and Langford 1969) or lamina propria of the seminiferous tubules (Clermont 1958). Our data suggest that the contractions of the seminiferous tubules induced by excitation of the adrenergic nerves may play an important role in the transport of spermatozoa through the tubules to the efferent ducts leading to the epididymis.…”

Section: Adrenergic Innervation Of the Myoid Cells 83mentioning

confidence: 99%

Pharmacological and histological evidence for adrenergic innervation of the myoid cells in the rat seminiferous tubule.

Miyake

Yamamoto

Mitsuya

1986

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Although the existence of seminiferous tubule contractions attributed to peritubular myoid cells is established, the control of the contractions is poorly understood. In this communication, it is shown that the rat seminiferous tubule responds to autonomic drugs and to stimulation of the perivascular nerve running along the spermatic vessels, by means of recording the intratubular pressure with a servo-null micropressure measuring device. Furthermore, the presence of nerve fibers close to the myoid cells is shown using a silver impregnation technique. Furthermore, the nature of the neurotransmitter contained in synaptic vesicles using 5-hydroxydopamine and L-DOPA as markers of adrenergic nerve elements with electron microscopy is shown in this report. It is concluded that there are adrenergic o -and f3-receptors and muscarinic receptors in myoid cells of the rat seminiferous tubule and that the contractions of seminiferous tubules are regulated by adrenergic nerve fibers. adrenergic innervation ; myoid cell ; seminiferous tubuleThe peritubular tissue (lamina propria) of seminiferous tubules from all mammals that have been examined to date contains cells that resemble smooth muscle, namely, myoid cells. These elements have been described in the rat (Niemi and Kormano 1965), human, mouse, hamster, rabbit, cat, sheep, pig and guinea pig. Contractility of these cells was first documented by Roosen-Runge (1951), who employed cinematography to record the motility of seminiferous tubules of rats and dogs. Many subsequent reports have dealt with the anatomy of these cells without attempting to record contractile events. The question of the regulation of these contractile movements has long remained unclear. Thus, it is significant to investigate the neurohumoral regulatory mechanism of the contractions of these cells and provide reasonable anatomical explanation for the innervation of contractile cells.

show abstract

Response of the Testicular Capsule to Acetylcholine and Noradrenaline

Cited by 40 publications

References 0 publications

The Autonomic Innervation of the Rat Testicular Capsule

The Autonomic Innervation of the Rat Testicular Capsule

Age-related differences in the response of the isolated testicular capsule of the rat to norepinephrine, acetylcholine and prostaglandins

Pharmacological and histological evidence for adrenergic innervation of the myoid cells in the rat seminiferous tubule.

Contact Info

Product

Resources

About