Response of X-Irradiated and Cryptorchid Testes to Endogenous Gonadotrophins in Parabiotic Rats

Johnson, Donald C.; Witschi, Emil

doi:10.1677/joe.0.0270193

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…Fogg and Cowing (1951) cited evidence proposed by other workers for an altered pituitary-testis axis. Some workers have shown that endogenic substances or pituitary gonadotrophins have a radioprotective action on the testis (Johnson and Witschi, 1963;Binhammer, 1967). Gunn et al (1960;, have since shown that androgen secretion by the testis is altered after radiation.…”

Section: Introductionmentioning

confidence: 99%

X-Ray induced changes in biochemical and histochemical parameters in the testis of male wild Indian house rate, <i>Rattus rattus</i>

Santra¹,

Manna

2010

Ceylon J. Sci. (Biol. Sci.)

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To observe the complementary effects, whole body of the male wild Indian house rat, Rattus rattus was irradiated with X-rays at 100 r, 200 r, 300 r and 500 r (single dose) doses. The changes in the histophysiological parameters of the testis were observed after 2, 7, 15 and 30 days of post treatment. Determination of biochemical parameters: ascorbic acid, cholesterol, acid and alkaline phosphatases in the testicular tissues indicated that concentrations of ascorbic acid and cholesterol (2 to 15 days post treatment) had increased while acid and alkaline phosphatases (2-30 days) had decreased. Changes in these parameters were observed in all four X-ray treated groups (100 r, 200 r, 300 r and 500 r). The histochemical study of the different X-ray treated groups clearly showed the intense accumulation of lipid substances and depletion of acid, alkaline phosphatases, 5-3-HSDH and 17-HSDH in the testicular tissues of 7 to 30 day-post treated groups exposed to 300 r and 500 r X-irradiation. In view of the changes observed in the testicular tissues, it is likely that a single dose of X-ray may cause certain histophysiological changes in the testis of wild rodents at least for certain periods. As a single dose of Xrays of 200r or 300r was sufficient to cause sterility in male rats, this may be included as a controlling agent that adversely effect the fertility of the rodent pests. Possible mode of action is discussed.

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Section: Introductionmentioning

confidence: 99%

X-Ray induced changes in biochemical and histochemical parameters in the testis of male wild Indian house rate, <i>Rattus rattus</i>

Santra¹,

Manna

2010

Ceylon J. Sci. (Biol. Sci.)

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Restriction of color in the rat with associated sterility in the male and heterochromia in both sexes

et al. 1972

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The effects of a new dominant gene in the rat are described. This gene, restricted (H' '), causes a marked restriction of the colored areas of the body i n the hooded, irish and self color patterns. Males with this restricted color pattern (Re) exhibit testicular tubular dysgenesis with consequent sterility, and a slightly reduced growth rate. The histological structure of the testis is described. Various experimental studies with the Re males are presented. These studies indicate that the cause of the sterility is a relative insensitivity of the germinal epithelium to pituitary follice-stimulating hormone. There is a high incidence of heterochromia i n Re rats with cream coat color and ruby eye.

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Effects of zinc on intact and castrated cockerels

Eltohamy¹,

Takahara²,

Okamoto³

1980

British Poultry Science

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1. Fourteen-week-old intact and castrated cockerels (White Leghorn) were injected intramuscularly with zinc (100 micrograms/kg body weight) as zinc ammonium sulphate solution once daily for 4 weeks and the effects on testes, pituitary and adrenal glands investigated histologically. 2. In intact cocks zinc decreased testes weight significantly, inhibited spermatogenesis and disturbed testicular hormone production. There was an increase in pituitary gonadotrophic cell activity, perhaps an indication of feed-back response to low concentration of testicular hormone. Cortical and medullary cells of the adrenal glands showed signs of activation. 3. No discernible effects of zinc injection on pituitary and adrenal cells of castrates were observed. This may reflect a decrease in pituitary and adrenal responsiveness to repeated stimulation with zinc. 4. The results indicate that the effectiveness of a given dose of zinc was dependent on the physiological condition of the cockerels and the effective site of zinc action was centred in the testes.

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Response of X-Irradiated and Cryptorchid Testes to Endogenous Gonadotrophins in Parabiotic Rats

Cited by 4 publications

References 7 publications

X-Ray induced changes in biochemical and histochemical parameters in the testis of male wild Indian house rate, <i>Rattus rattus</i>

X-Ray induced changes in biochemical and histochemical parameters in the testis of male wild Indian house rate, <i>Rattus rattus</i>

Restriction of color in the rat with associated sterility in the male and heterochromia in both sexes

Effects of zinc on intact and castrated cockerels

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