Coordinated uptake and utilization of water and nitrogen (N) is important for high-yield and high-efficiency cultivation of winter wheat. The relationship between soil water consumption and N uptake and utilization has not previously been widely investigated. The purpose of this study was to examine the regulatory effects of different seeding rates with wide-space sowing on water consumption and N accumulation and translocation of winter wheat. A field experiment was conducted in the southeastern part of the Loess Plateau between 2016 and 2018, in which winter wheat was sown using the wide-space method (row spacing: 22-25 cm, and seedling bandwidth: 5-8 cm) and five seeding rates: 150, 225, 300, 375, and 450 kg seeds ha −1 . The results showed that soil water consumption increased significantly with an increase in the seeding rate from 150-300 kg seeds ha −1 , especially from the jointing to maturity stage of wheat growth. At 300 kg seeds ha −1 , N translocation from the leaf and stem + sheath to the grains was significantly enhanced, which increased grain N accumulation. The maximum tiller number, water use efficiency, N uptake efficiency, and partial factor productivity from applied N were all recorded at a seeding rate of 300 kg seeds ha −1 , thus, grain yield increased significantly by 6-18%. Correlation analysis showed that N accumulation from the sowing to anthesis stage, pre-anthesis N translocation, and the grain yield of winter wheat were closely related to total soil water consumption. Overall, the findings of this study have demonstrated that widespace sowing of winter wheat at a 300 kg seeds ha −1 seeding rate improved the water use efficiency and N uptake efficiency, which in turn increased the tiller number and grain yield.