Response Pattern Based on the Amplitude of Ear Canal Recorded Cochlear Microphonic Waveforms across Acoustic Frequencies in Normal Hearing Subjects

Zhang, Ming

doi:10.1177/1084713812448547

Cited by 11 publications

(10 citation statements)

References 47 publications

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“…These three paradigms, and thus evoked CMs, have been previously discussed and addressed. 16 Based on this previous report, only a couple of period cycles appear in a click-evoked CM, which is represented by ringing of the basilar membrane and represents activities associated with many frequencies. 56 , 57 Compared to click-evoked CMs, a short toneburst evoked CM contains more periods of cycles and represents fewer frequencies, and therefore, is more frequency specific.…”

Section: Discussionmentioning

confidence: 98%

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Effects of Stimulus Intensity on Low-Frequency Toneburst Cochlear Microphonic Waveforms

Zhang

2013

Audiology Research

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This study investigates changes in amplitude and delays in low-frequency toneburst cochlear microphonic (CM) waveforms recorded at the ear canal in response to different stimulus intensities. Ten volunteers aged 20-30 were recruited. Low-frequency CM waveforms at 500 Hz in response to a 14-ms toneburst were recorded from an ear canal electrode using electrocochleography techniques. The data was statistically analyzed in order to confirm whether the differences were significant in the effects of stimulus intensity on the amplitudes and delays of the low-frequency CM waveforms. Electromagnetic interference artifacts can jeopardize CM measurements but such artifacts can be avoided. The CM waveforms can be recorded at the ear canal in response to a toneburst which is longer than that used in ABR measurements. The CM waveforms thus recorded are robust, and the amplitude of CM waveforms is intensity-dependent. In contrast, the delay of CM waveforms is intensity-independent, which is different from neural responses as their delay or latency is intensity-dependent. These findings may be useful for development of the application of CM measurement as a supplementary approach to otoacoustic emission (OAE) measurement in the clinic which is severely affected by background acoustic noise. The development of the application in the assessment of low-frequency cochlear function may become possible if a further series of studies can verify the feasibility, but it is not meant to be a substitute for audiometry or OAE measurements. The measurement of detection threshold of CM waveform responses using growth function approach may become possible in the clinic. The intensity-independent nature of CMs with regards to delay measurements may also become an impacting factor for differential diagnoses and for designing new research studies.

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Section: Discussionmentioning

confidence: 98%

“…13 , 14 In addition, we have addressed high frequency CMs in two recent articles in 2012. 15 , 16 Therefore, we focus on the low-frequency CM in this report by extending our attention to one more factor, intensity dependence.…”

Section: Introductionmentioning

confidence: 99%

Effects of Stimulus Intensity on Low-Frequency Toneburst Cochlear Microphonic Waveforms

Zhang

2013

Audiology Research

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“…One of the limitations here is that this study used only click stimuli as opposed to pure tone stimuli to perform ECochG, and hence our results lack tone specificity. Current clinical reports indicate more consistent findings with low-frequency tone bursts (Hornibrook et al 2012;Iseli and Gibson 2010;Zhang 2012). It is possible that tone bursts might yield more reliable findings.…”

Section: Limitations Of the Study And Future Directionsmentioning

confidence: 87%

A Mouse Model Validates the Utility of Electrocochleography in Verifying Endolymphatic Hydrops

Melki

Semaan

et al. 2014

JARO

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Endolymphatic hydrops (ELH) is a disorder of the inner ear that causes tinnitus, vertigo, and hearing loss. An elevated ratio of the summating potential (SP) to the action potential (AP) measured by electrocochleography has long been considered to be the electrophysiological correlate of ELH-related clinical conditions, such as Meniere's disease, but in vivo confirmation and correlation between an elevated SP/AP ratio and ELH has not yet been possible. Confirming this relationship will be important to show that elevated SP/AP ratio is indeed diagnostic of ELH. Here, we sought to confirm that an elevated SP/AP ratio is associated with ELH and test the hypothesis that severity of ELH and hearing loss would also correlate with the SP/AP ratio in vivo using the Phex(Hyp-Duk)/Y mouse model of postnatal ELH. In addition, we describe a minimally invasive approach for electrocochleography in mice. Auditory brainstem responses and electrocochleography data were collected from controls and Phex(Hyp-Duk)/Y mutants at postnatal day 21 and the mice (all male) were euthanized immediately for cochlear histology. Our results show that (1) the SP/AP ratio was significantly elevated in mice with histological ELH compared to controls, (2) the SP/AP ratio was not correlated with the severity of histological ELH or hearing loss, and (3) the severity of hearing loss correlated with the severity of histological ELH. Our study demonstrates that an elevated SP/AP ratio is diagnostic of ELH and that the severity of hearing loss is a better predictor of the severity of ELH than is the SP/AP ratio.

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Section: Introductionmentioning

confidence: 99%

“…Other research has involved the use of a canal electrode rather than a concha electrode to measure response patterns of CM waveforms (Zhang 2012). As previously described, the CMWs are still CMs but contain multiple sinusoidal waveforms evoked by a relatively long tone burst (e.g., 14 msec) (Zhang 2012). In this study, we are investigating the use of a concha electrode in measuring CMWs at different acoustic frequencies and analyze the response pattern based on the amplitude of the CMWs across these frequencies.…”

Section: Introductionmentioning

confidence: 99%

Using a Concha Electrode to Measure Response Patterns Based on the Amplitudes of Cochlear Microphonic Waveforms Across Acoustic Frequencies in Normal-Hearing Subjects

Zhang

2015

Ear &Amp; Hearing

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We confirmed a measurable CMW response pattern using the concha electrode. We propose that the pattern's features may be partly due to variation along the cochlea of the activities and volume of hair cells and possibly also the physical properties of the basilar membrane. The clinical importance of these results may be related mainly to seven features of the CMW, including electrode locations, response patterns, inclusion of low frequencies, and uniqueness of CMWs (versus otoacoustic emissions, auditory brainstem responses, shorter stimulus, and audiograms). Limitations, such as signal to noise ratio, also exist. After further study, the concha electrode may be used in the clinic and in research, and the response pattern may be used to interpret the CMW measurement.

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Response Pattern Based on the Amplitude of Ear Canal Recorded Cochlear Microphonic Waveforms across Acoustic Frequencies in Normal Hearing Subjects

Cited by 11 publications

References 47 publications

Effects of Stimulus Intensity on Low-Frequency Toneburst Cochlear Microphonic Waveforms

Effects of Stimulus Intensity on Low-Frequency Toneburst Cochlear Microphonic Waveforms

A Mouse Model Validates the Utility of Electrocochleography in Verifying Endolymphatic Hydrops

Using a Concha Electrode to Measure Response Patterns Based on the Amplitudes of Cochlear Microphonic Waveforms Across Acoustic Frequencies in Normal-Hearing Subjects

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