Response Perseveration Following the Hippocampal Ablation in the Rat

Niki, Hiroaki

doi:10.4992/psycholres1954.8.1

Cited by 58 publications

(18 citation statements)

References 23 publications

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“…3A,5A,B). This could be related to the previous observation showing that hippocampal animals are impaired in internal inhibition (Pavlov, 1927) or "behavioral inhibition" (Douglas, 1967;Kimble, 1968), which resulted in perseveration of the CR in response to the CS (Niki, 1966;Kim et al, 1995;Chan et al, 2001). These results suggest that CA3 NRs may function to exclude CS from attention to protect memory from interference.…”

Section: Ca3-nr1 Ko Mice Are Impaired In "Internal Inhibition"supporting

confidence: 67%

Hippocampal CA3 NMDA Receptors Are Crucial for Adaptive Timing of Trace Eyeblink Conditioned Response

Kishimoto

Nakazawa²,

Tonegawa³

et al. 2006

J. Neurosci.

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Classical conditioning of the eyeblink reflex is a simple form of associative learning for motor responses. To examine the involvement of hippocampal CA3 NMDA receptors (NRs) in nonspatial associative memory, mice lacking an NR1 subunit selectively in adult CA3 pyramidal cells [CA3-NR1 knock-out (KO) mice] were subjected to eyeblink conditioning paradigms. Mice received paired presentations of an auditory conditioned stimulus (CS) and a periorbital shock unconditioned stimulus (US). With repeated presentation of the CS followed by the US, wild-type mice learned to blink in anticipation of the US before its onset. We first confirmed that wild-type mice require an intact hippocampus in the trace version of eyeblink conditioning in which the CS and US do not overlap, creating a stimulusfree time gap of 500 ms. Under the same condition, CA3-NR1 KO mice successfully acquired conditioned responses (CRs) during the 10 d acquisition sessions, whereas the extinction of CRs was impaired on the first day of extinction sessions. Importantly, CA3-NR1 KO mice were impaired in the formation of an adaptively timed CR during the first five trials in the daily acquisition sessions. The aberrantly timed CR was also observed in the extinction sessions in accordance with the impaired extinction of CRs. These results indicate that CA3-NR1 KO mice are unable to rapidly retrieve adaptive CR timing, suggesting that CA3 NRs play a crucial role in the memory of adaptive CR timing in trace conditioning.

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Section: Ca3-nr1 Ko Mice Are Impaired In "Internal Inhibition"supporting

confidence: 67%

Hippocampal CA3 NMDA Receptors Are Crucial for Adaptive Timing of Trace Eyeblink Conditioned Response

Kishimoto

Nakazawa²,

Tonegawa³

et al. 2006

J. Neurosci.

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“…In a Dashiell maze, for example, rats with various neocortical (Krechevsky, 1937a) or hippocampal (Niki, 1966) lesions were found to be less flexible in choosing different paths than were the controls. Similar findings have been reported in other maze-type situations (Hirsh, 1970;Krechevsky, 1937bKrechevsky, , 1938Niki, 1966).…”

Section: Detour Problem-solving Behavior 121mentioning

confidence: 99%

“…Although the animals of Group 0 performed poorly on Trial 1 of Problem B, a result that probably was due to a visual defect, they were able to find the correct detour path on Problems A and C about as efficiently as the controls. Hirsh (1970) and Niki (1966) have likewise failed to demonstrate that occipitally damaged rats are deficient in variability of responses, as gauged by performance on a four-choice task and a Dashiell maze, respectively. One likely explanation for these conflicting findings may lie in the fact that the early Krechevsky and Lashley studies contained a number of animals with occipitallesions that invaded significant portions of the parietal cortex; as a consequence of these cases with overlapping damage, the presence of a localized cortical effect on the problems investigated might have been obscured.…”

Section: Detour Problem-solving Behavior 121mentioning

confidence: 99%

Detour problem-solving behavior in rats with neocortical and hippocampal lesions: A study of response flexibility

1984

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Young rats previously subjected to discrete neocortical ablations or hippocampal electrolytic lesions received five trials on each of three "climbing" detour problems. Performance on Trial! (a measure of response flexibility) of each problem was significantly impaired in those groups with frontal, parietal, or hippocampallesions; the group with occipitallesions was impaired on only one problem. Performance on Trials 2-5(a measure of detour habit formation) of each problem was significantly impaired only in the hippocampal group; the neocortical groups showed either no impairment or a mild impairment on these trials. These results suggest that the solution of detour problems on the first trial may require a cognitive process that is qualitatively different from that required on subsequent trials.

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“…Hippocampally damaged adults are not typically impaired in the acquisition of a position habit (Kimble & Kimble. 1965: Niki. 1966).…”

Section: ~mentioning

confidence: 99%

An age related position reversal impairment in the rat

Harley

Moody

1973

Psychobiology

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Response Perseveration Following the Hippocampal Ablation in the Rat

Cited by 58 publications

References 23 publications

Hippocampal CA3 NMDA Receptors Are Crucial for Adaptive Timing of Trace Eyeblink Conditioned Response

Hippocampal CA3 NMDA Receptors Are Crucial for Adaptive Timing of Trace Eyeblink Conditioned Response

Detour problem-solving behavior in rats with neocortical and hippocampal lesions: A study of response flexibility

An age related position reversal impairment in the rat

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