Response Prediction of Altered Thyroglobulin Levels After Radioactive Iodine Therapy Aided by Recombinant Human Thyrotropin in Patients with Differentiated Thyroid Cancer

Song, Minchul; Jeon, Subin; Kang, Sae-Ryung; Jabin, Zeenat; Yoo, Su Woong; Min, Jung‐Joon; Bom, Hee‐Seung; Cho, Sang-Geon; Kim, Jahae; Song, Ho‐Chun; Kwon, Seong

doi:10.1007/s13139-018-0528-7

Cited by 2 publications

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“…Patients with negative or non-specific findings on US and/or follow-up WBS and either non-stimulated Tg < 1 ng/mL or stimulated Tg < 10 ng/mL were categorized as the acceptable response (AR) group, while those with evidence of persistent or newly developed lesions on imaging studies or non-stimulated Tg level ≥1 ng/mL or stimulated Tg level ≥10 ng/mL or rising TgAbs level were considered as the non-acceptable response (non-AR) group. [ 11 – 13 ]…”

Section: Methodsmentioning

confidence: 99%

Optimization of serum thyroglobulin measured at different time points for prognostic evaluation in differentiated thyroid carcinoma patients

et al. 2020

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Although serum thyroglobulin (Tg) is a reliable differentiated thyroid carcinoma (DTC) prognostic marker, its cutoff values can be affected by TSH stimulation status. Serum Tg prognostic values measured at different time points before and after radioactive iodine (RAI) therapy prepared with recombinant human TSH (rhTSH) in DTC patients, were investigated. This study included 160 DTC patients who underwent surgery followed by rhTSH-aided RAI therapy. Their serum Tg levels were measured 7 days before (D-7Tg), on the day of (D0Tg), and 2 days after (D2Tg) the RAI therapy. For response evaluation, the patients were classified into 2 groups: acceptable response and non-acceptable response (non-AR). Optimal Tg level cutoff values measured at different time points were evaluated for persistent or recurrent disease (PRD) prediction, as well as therapeutic response. Multivariate analysis showed that D-7Tg, D0Tg, and D2Tg significantly predicted non-AR ( P < .05, for all). Optimal Tg level cutoff values for non-AR prediction were 0.6, 2.6, and 3.7 ng/mL for D-7Tg, D0Tg, and D2Tg, respectively. Cox regression analysis showed that Tg levels were significantly associated with PRD free survival with D-7Tg, D0Tg, and D2Tg cutoff values of 0.8, 4.0, and 6.0 ng/mL, respectively (D-7Tg, P = .010; D0Tg, P = .005; D2Tg, P = .011). Serum Tg levels measured at the different time points could predict PRD free survival as well as therapeutic response with different cutoff values in DTC patients who underwent rhTSH-aided RAI therapy.

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Section: Methodsmentioning

confidence: 99%

Optimization of serum thyroglobulin measured at different time points for prognostic evaluation in differentiated thyroid carcinoma patients

et al. 2020

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Role of thyroglobulin in the management of patients with differentiated thyroid cancer

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Yang

et al. 2019

Clin Transl Imaging

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Response Prediction of Altered Thyroglobulin Levels After Radioactive Iodine Therapy Aided by Recombinant Human Thyrotropin in Patients with Differentiated Thyroid Cancer

Abstract: Altered levels of serum Tg after RAI therapy, calculated as the ratioTg (D7Tg/D0Tg), significantly predicted an acceptable response in patients with DTC.

Cited by 2 publications

References 18 publications

Optimization of serum thyroglobulin measured at different time points for prognostic evaluation in differentiated thyroid carcinoma patients

Optimization of serum thyroglobulin measured at different time points for prognostic evaluation in differentiated thyroid carcinoma patients

Role of thyroglobulin in the management of patients with differentiated thyroid cancer

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