Response rate and predictors of response in a short‐term empirical trial of high‐dose rabeprazole in patients with globus

Sinn, Dong Hyun; Kim, J. H.; Kim, S.; Son, Hee Jung; Kim, J. J.; Rhee, Jong Chul; Rhee, Poong‐Lyul

doi:10.1111/j.1365-2036.2008.03659.x

Cited by 46 publications

(36 citation statements)

References 23 publications

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“…These results are in compliance with Hp prevalence studies conducted in Turkey (prevalence of Hp in Turkey is between 48% and 68%) (16,17). The correlation between globus hystericus and GERD was investigated in previous studies, but the exact cause was not fully explained (3,18). Sinn et al (18) showed that GERD symptoms were positive in 64% of cases with symptoms of globus.…”

Section: Discussionsupporting

confidence: 67%

“…In our study, the reflux symptoms were positive in 32 (26%) of the cases with symptoms of GS. This result was lower than in the study by Sinn et al (18), but it complies with results of epidemiological reflux studies conducted in our country (16,17). In the present study, PPI (30 mg/day) was administered to Hp(-) cases with dyspepsia and/or reflux symptoms (endoscopic, clinic).…”

Section: Discussioncontrasting

confidence: 55%

“…The correlation between globus hystericus and GERD was investigated in previous studies, but the exact cause was not fully explained (3,18). Sinn et al (18) showed that GERD symptoms were positive in 64% of cases with symptoms of globus. However, the improvement in the typical reflux symptoms had no association with improvement in globus symptoms after two weeks of PPI treatment.…”

Section: Discussionmentioning

confidence: 99%

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Does Helicobacter pylori treatment improve the symptoms of globus hystericus?

Kasap

Ayhan²,

Yüceyar³

2012

Turk J Gastroenterol

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Section: Discussionsupporting

confidence: 67%

Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

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Does Helicobacter pylori treatment improve the symptoms of globus hystericus?

Kasap

Ayhan²,

Yüceyar³

2012

Turk J Gastroenterol

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“…However, the effectiveness of hangekobokuto in patients who were prescribed ICS/LABA simultaneously to hangekobokuto could not be estimated due to the small number of patients, although ICS/LABA was not a predictive factor of the response to hangekobokuto on SLT in the multiple regression analysis (Table III). Second, certain previous studies have suggested that GERD may be a major factor of SLT (7,8). By contrast, other studies did not support GERD as an etiology of SLT (9).…”

Section: Discussionmentioning

confidence: 44%

“…The etiology of SLT appears to be multifactorial, and the psychological characteristics, stress and pressure of a psychiatric disorder may be significant factors in SLT (5). In addition, certain studies suggested that bronchial asthma (6), and gastroesophageal reflux disease (GERD) may be major factors of SLT (7,8). Hangekobokuto (Tsumura Co., Tokyo, Japan), one of the traditional herbal medicines that has been developed by Zhang Zhongjing, a well-known physician of traditional Chinese medicine in the third century, is known as an effective drug on SLT in North-East Asia (9).…”

Section: Introductionmentioning

confidence: 99%

Effect of a traditional herbal medicine, hangekobokuto, on the sensation of a lump in the throat in patients with respiratory diseases

et al. 2016

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Abstract. The sensation of a lump in the throat (SLT) is not a rarely encountered symptom. The etiology of SLT appears to be multifactorial, and the psychological characteristics, stress and pressure of a psychiatric disorder may be significant factors in SLT. Hangekobokuto, one of the traditional herbal medicines, is a known drug that has an effect on SLT. The efficacy of a short-term hangekobokuto treatment on SLT was evaluated. To assess whether a 2-week prescription of hangekobokuto improves SLT mainly in patients with respiratory diseases, a retrospective study was performed between April 2013 and August 2015. During the study period, a total of 43 patients were treated with hangekobokuto. Twelve (27.9%) of the 43 patients were reported to experience completely effective treatment (SLT completely disappeared), and 14 (32.6%) experienced moderately effective treatment (25-99% SLT disappeared). Patients with bronchial asthma and those without a medical history of respiratory disease exhibited a good response to hangekobokuto. No specific predictive factor of the response to hangekobokuto on SLT was identified in the multivariate regression analysis. Therefore, the present results suggested that hangekobokuto could be one of the treatment choices for uncontrolled SLT.

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Surgical Treatment for Laryngopharyngeal Reflux Disease

Lechien

Dapri

Dequanter

et al. 2019

JAMA Otolaryngol Head Neck Surg

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IMPORTANCE Laryngopharyngeal reflux (LPR) is a prevalent disease that is usually treated with diet, lifestyle modifications, and proton pump inhibitor therapy. However, nearly 10% to 30% of patients do not achieve adequate acid suppression even with high doses of proton pump inhibitors. For these patients with resistant disease, fundoplication may be recommended but the success rate of fundoplication surgery on laryngopharyngeal symptoms and findings remains uncertain. OBJECTIVE To determine whether fundoplication is associated with control of signs and symptoms in patients with LPR.EVIDENCE REVIEW A literature search was conducted on PubMed, Cochrane Library, and Scopus according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guideline to identify studies published between 1990 and 2018 about the efficacy of fundoplication on clinical outcomes of LPR. Three investigators screened publications for eligibility and exclusion based on predetermined criteria. Study design, patient characteristics, diagnostic method, exclusion criteria, treatment characteristics, follow-up, and quality of the outcome assessment were evaluated.FINDINGS Of the 266 studies identified, 34 met the inclusion criteria, accounting for 2190 patients with LPR (1270 women and 920 men; mean [SD] age at the time of surgery, 49.3 [6.3] years). A weighted mean of 83.0% of patients (95% CI, 79.7%-86.3%) experienced improvement and a weighted mean of 67.0% of patients (95% CI, 64.1%-69.9%) experienced a disappearance of symptoms, but there is a high level of methodological heterogeneity among studies according to diagnostic method, exclusion criteria, and outcomes used to assess the efficacy of fundoplication. A pH study without impedance study was used in most studies but with various inclusion criteria. According to results of an a priori assessment, the clinical outcomes used were overall poor, excluding many symptoms and findings associated with LPR. CONCLUSION AND RELEVANCEThe reported studies of fundoplication in LPR disease have important heterogeneity in method of diagnosis, exclusion criteria, symptoms, and signs assessed as therapeutic outcomes; therefore, this systematic review was nonconclusive regarding whether surgery for LPR disease is associated with effective control of sight and symptoms. Otolaryngologists, gastroenterologists, and surgeons must establish a diagnostic criterion standard, clear indications for surgery, and future clinical outcomes to precisely assess the effectiveness of treatment.

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Response rate and predictors of response in a short‐term empirical trial of high‐dose rabeprazole in patients with globus

Cited by 46 publications

References 23 publications

Does Helicobacter pylori treatment improve the symptoms of globus hystericus?

Does Helicobacter pylori treatment improve the symptoms of globus hystericus?

Effect of a traditional herbal medicine, hangekobokuto, on the sensation of a lump in the throat in patients with respiratory diseases

Surgical Treatment for Laryngopharyngeal Reflux Disease

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