Response speed, contingent negative variation and P300 in Alzheimer’s disease and MCI

Deursen, Jeroen A. van; Vuurman, E.F.P.M.; Smits, Lieke; Verhey, Frans R.J.; Riedel, Wim J.

doi:10.1016/j.bandc.2008.12.007

Cited by 84 publications

(66 citation statements)

References 49 publications

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“…The P300 latency may be more sensitive than neuropsychological tests in the longitudinal follow-up of AD patients when it reflects cognitive decline [31]. The P300 amplitude and latency also distinguished the groups and showed a significant correlation with response speed [32].…”

Section: Discussionmentioning

confidence: 93%

Analysis of EEG Complexity in Patients with Mild Cognitive Impairment

Zhu¹,

Chai²,

Gao³

et al. 2017

J Neurol Disord

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Section: Discussionmentioning

confidence: 93%

Analysis of EEG Complexity in Patients with Mild Cognitive Impairment

Zhu¹,

Chai²,

Gao³

et al. 2017

J Neurol Disord

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“…An important degree of freedom is the EEG recording condition: one may record EEG: (i) while the subject is at rest (with open or closed eyes); (ii) while the subject performs working-memory or other tasks; (iii) while the subject is being stimulated with auditory, visual, tactile, or other signals (see, e.g., [11][12][13][14][15]). Depending on the recording situation, EEG signals may be more or less discriminative for MCI and AD; a systematic exploration of different recordings conditions with the aim of diagnosing MCI and AD needs to be conducted.…”

Section: Resultsmentioning

confidence: 99%

On the Early Diagnosis of Alzheimer’s Disease from EEG Signals: A Mini-Review

Dauwels

Vialatte

Cichocki

2010

Advances in Cognitive Neurodynamics (II)

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“…Previous research reported that the P3 latency was stable and sensitive in cognitive evaluations of MCI patients and those with conversion from MCI to AD [23]. Indeed, a number of experimental studies also demonstrated prolonged P3 latency in the elderly with aMCI [21,72] and MCI [73][74][75] when performing the visual and auditory oddball tasks. Therefore, in support of these earlier findings, the prolonged P3 latency found in the current paper seems to be a neuropathological characteristic of MCI.…”

Section: Discussionmentioning

confidence: 94%

The Role of Physical Fitness in the Neurocognitive Performance of Task Switching in Older Persons with Mild Cognitive Impairment

Tsai

Pai

Ukropec

et al. 2016

JAD

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Abstract. Although elderly people with amnestic mild cognitive impairment (aMCI) have been found to show impaired behavioral performance in task switching, no research has yet explored the electrophysiological mechanisms and the potential correlation between physical fitness and neurocognitive (i.e., behavioral and electrophysiological) performance in aMCI. The present study was thus aimed to examine whether there are differences in electrophysiological (i.e., event-related potential) performance between aMCI participants and controls when performing a task-switching paradigm, and to investigate the role of physical fitness in the relationship between neurocognitive performance and aMCI. Sixty participants were classified into aMCI (n = 30) and control (n = 30) groups, and performed a task-switching paradigm with concomitant electrophysiological recording, as well as underwent senior functional physical fitness tests. The aMCI group showed comparable scores on most parts of the physical fitness tests, but reduced lower body flexibility and VO 2max as compared to the control group. When performing the task-switching paradigm, the aMCI group showed slower reaction times in the heterogeneous condition and larger global switching costs, although no significant difference was observed in accuracy rates between the two groups. In addition, the aMCI group showed significantly prolonged P3 latencies in the homogeneous and heterogeneous conditions, and a smaller P3 amplitude only in the heterogeneous condition. The level of cardiorespiratory fitness was significantly correlated with P3 amplitude in the aMCI group, particularly in the heterogeneous condition of the task-switching paradigm. These results show that the aMCI group exhibited abnormalities in their neurocognitive performance when performing the task-switching paradigm and such a deficit was likely associated with reduced cardiorespiratory fitness, which was shown to be the important predictor of neurocognitive performance.

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Response speed, contingent negative variation and P300 in Alzheimer’s disease and MCI

Cited by 84 publications

References 49 publications

Analysis of EEG Complexity in Patients with Mild Cognitive Impairment

Analysis of EEG Complexity in Patients with Mild Cognitive Impairment

On the Early Diagnosis of Alzheimer’s Disease from EEG Signals: A Mini-Review

The Role of Physical Fitness in the Neurocognitive Performance of Task Switching in Older Persons with Mild Cognitive Impairment

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