Response surface methodology approach for the preparation of a molecularly imprinted polymer for solid‐phase extraction of fenoxycarb pesticide in mussels

Abstract

The aim of this work was to develop an efficient method for the selective extraction and analysis of fenoxycarb, a carbamate pesticide, in mussel samples using a molecularly imprinted solid‐phase extraction device. The optimization of molecularly imprinted polymer synthesis was performed using the experimental design under the response surface methodology approach. A fast rebinding study and Freundlich isotherm adsorption were carried out to calculate binding capacity B, site number n, and affinity constant Kf. The optimum molecularly imprinted polymer was successfully used as sorbent of a solid‐phase extraction cartridge for the determination of fenoxycarb in real mussel samples. The range of linearity was 0.3–30 mg/L with a correlation coefficient of 0.991. The limit of detection was 0.247 mg/kg. The recovery of fenoxycarb extracted from mussel samples of Mediterranean sea was 97% (n = 3) with relative standard deviation between 6 and 7% proving the reliability of the developed method.

Imprinting Technology for Effective Sorbent Fabrication: Current State-of-Art and Future Prospects

“…The molecularly imprinted sorbents were utilized in the food analysis for determination of antibiotics such as norfloxacin [121] or cephalexin in pork [122], tetracycline in chicken [123], aminoglycosides (streptomycin, kanamycin, and gentamycin) in various milk samples [124], chloramphenicol in honey [125], zearalenone in wheat [126], estrogens (estrone, estriol, and estragon) in milk [127] or in cucumber, milk powder and grass carp samples [128], sulfonamides such as sulfamethoxazole in milk [129], imidacloprid [130] or kaempherol in apples [131], patulin in apple juice [132], hesperidin in lime juice [133], strobilurin in peach [134], carbendazim in orange [135], dopamine in bananas [136], fenoxycarb in mussels [137], phenylarsonic compounds in chicken and pork samples [138], or organochlorine fungicides in ginseng samples [139], acrylamide in biscuits [140], bisphenoles A [141] as well as F and S (on imprinted commercial sorbent-Affinimip ® ) [142], and quercetin in onion [143]. The imprinted sorbents were also used for selective extraction of plant ingredients, such as rosmarinic acid from Rosmarinus officinalis L. [144], tannins from the barks of Anadenanthera macrocarpa var.…”

The Use of Computational Methods for the Development of Molecularly Imprinted Polymers

“…The inherent flexibility of MIP synthesis and the interdependence of the variables makes this stage a good candidate for multivariate optimization. Consequently, a number of studies have been published applying different multivariate methods and experimental designs in order to optimize polymer composition and/or synthesis methods [ 210 , 211 , 212 , 213 , 305 , 429 , 430 , 431 , 432 , 433 , 434 , 435 , 436 , 437 , 438 , 439 , 440 , 441 , 442 , 443 , 444 , 445 , 446 , 447 , 448 , 449 , 450 , 451 , 452 , 453 , 454 , 455 , 456 , 457 , 458 , 459 , 460 , 461 , 462 , 463 , 464 , 465 , 466 , 467 , 468 , 469 , 470 , 471 , 472 ,…”

Raclopride-Molecularly Imprinted Polymers: A Promising Technology for Selective [11C]Raclopride Purification

“…In addition, the storage life of imprinted polymers can be very high (several years at room temperature), and after washing can be reused many times without losing their recognition ability. These important properties make molecularly imprinted polymers (MIPs) suitable for their use in a lot of application fields, such as chemical separation, catalysis, and electrochemical sensing [ 11 , 15 , 17 , 18 ].…”

“…The present work is focused on the development of a novel purification approach for [ 11 C]RAC that will exploit specifically tailored shape-recognition polymers with the aim to substitute the standard single-pass HPLC purification with an in-flow trap and release sequence. In particular, MIT applied to solid phase extraction (MISPE) [ 14 , 18 , 19 , 20 ] was studied in order to develop a setting able to selectively extract [ 11 C]RAC in a mixture containing a high amount of its precursor, DM-RAC, a condition that occurs after [ 11 C]RAC radiolabeling step. To prepare two MIPs able to bind unlabeled RAC and DM-RAC, a thermal polymerization was used.…”