Response Surface Methodology as an Approach for Optimization of the Synthesis of 1-(2-Aminoethyl)-2-imidazolidone

Abstract

Ruthenium loaded on activated carbon pre-treated by HNO 3 was used to catalyze the reaction of 1-(2-Aminoethyl)-2-imidazolidone (AEI) synthesized from ethylenediamine, ethanolamine and CO 2 . Response surface methodology (RSM) based on Box-Behnken design (BBD) was employed to optimize the synthesis of AEI. The statistical analysis results showed that the yield of AEI was significantly affected by the CO 2 pressure, reaction temperature and reaction time. According to the results of variance analysis, the value of the determination coefficient of 0.9854 was in reasonable agreement with the "Adj R-Squared" of 0.9666, which means this model can predict the yield of AEI well and can be used to optimize reaction conditions for higher AEI yield. The optimal values of AEI yield predicted by RSM was 84.9% under temperature 206.51˚C, CO 2 pressure 9.35 Mpa, reaction time 10.11 h, and the verification experiment yield of AEI was 83.1%.

Salicylic aldehyde-n(4)-(4-ethoxyanilinyl) thiosemicarbazone: optimization of synthesis by surface response and structural characteristics

“…Beside structuring H2L by analysis of IR, UV-Vis, MS and NMR, its acidic dissociation constants and the ability to prevent cancer cells from growing in human body were also carried out in this research. In addition, optimizing the synthesis process to find the maximum yield was estimated by using a surface response model which is an effective method to eliminate the limitations of the one-variable-at-a-time (OVAT) approach (He and Zhang, 2017;Chen, et al, 2015;Dutta et al 2015;Sabelaet al 2014;Lang et al 2006;Long et al 2017;Sarrai et al 2016;Matlob et al 2012;Somani et al 2011;Tang et al 2013).…”