Response Surface Methodology for an Improved Nanoemulsion of Ivacaftor &amp;amp; Its Optimisation for Solubility and Stability

Parihar, Akshay; Prajapati, Bhupendra Gopalbhai

doi:10.51847/izavr2gt5p

Pharmacophore

2023

DOI: 10.51847/izavr2gt5p

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Response Surface Methodology for an Improved Nanoemulsion of Ivacaftor & Its Optimisation for Solubility and Stability

Akshay Parihar,

Bhupendra Gopalbhai Prajapati

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Cited by 2 publications

References 37 publications

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Preparation, Characterization, and Sub-Chronic Toxicity of Carvacrol-Self-Nano-Emulsifying Drug Delivery System Towards Healthy Sprague Dawley Rats

Maarouf,

Rahman

2024

Natural Product Communications

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Background: Carvacrol (CAR) is the active component in essential oils (EOs) of many fragrant plants, including oregano and thyme; however, its high toxicity restricts its usage in biomedical fields, and the self-nano-emulsifying drug delivery system (SNEDDS) was suggested to overcome this issue. Objective: To prepare and characterize the CAR-loaded SNEDDS and to assess its toxicity profile towards healthy rats using the in vivo sub-chronic study. Methods: SNEDDS was prepared from olive oil, dimethyl sulfoxide, Tween-80, and distilled water, then CAR-SNEDDS was prepared by adding 0.5% CAR to SNEDDS and both composites were gently agitated for 72 h at room temperature. Later on, both composites were physiochemically characterized for size/charge (Zetasizer), shape (TEM), crystallinity (XRAD), composition (FTIR), and quantitated (UV–Vis). Additionally, the sub-chronic toxicity of both composites at different doses was conducted by orally treating healthy Sprague Dawley for 4 weeks. Then, the treated rats were checked for toxicological symptoms, food/water intake, and behavioral abnormality. In addition, the blood samples were tested for hematologic/biochemical changes, while vital organs (liver and kidney) were assessed for histopathological alterations. Results: The average globule size, zeta potential, and polydispersity index of CAR-SNEDDS were 158.93 ± 22.18 nm, −22.56 ± 1.77 mV, 0.553 ± 0.31, respectively. All treated animal tissues, serum biochemical profiles, and total hemograms were normal. At 30-90 mg/kg oral doses, CAR-SNEDDS was not toxic and did not cause mortality. Conclusions: CAR-SNEDDS was successfully synthesized and characterized, and the results from sub-chronic oral toxicity studies showed that the CAR-SNEDDS were non-toxic and safe for biomedical fields.

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Preparation, Characterization, and Sub-Chronic Toxicity of Carvacrol-Self-Nano-Emulsifying Drug Delivery System Towards Healthy Sprague Dawley Rats

Maarouf,

Rahman

2024

Natural Product Communications

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Dissolution Rate Enhancement of Dolutegravir Sodium Through Nanosuspension Technology Using 3 2 Factorial Design

Rodriques<#%##>,

Gopalbhai

2023

Int J Pharm Phytopharmacol Res

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Dolutegravir Sodium is a potent antiretroviral medication used in the treatment of HIV. It is BCS Class II compound and is practically insoluble at normal gastric pH range. The research aimed to discover and optimize operational and formulation factors that affect the characteristics of the drug. 3 2 factorial design was utilized for the investigation. PVP K30, Polyvinyl Alcohol, Polxammer 407, and Polxammer 188 were used in preparation of nanosupension. The formulation variables tested were the polymer concentration, whereas the manufacturing variable was homogenization speed. Particle size and saturation solubility were two responses that were assessed in this investigation. The results of the analysis of variance show that the polymer concentration and homogenization speed significantly impact the saturation solubility and particle size of the nanosuspension. The contour plot and resulting polynomial formula assist in estimating the values of chosen independent factors to develop the best nanosuspension formulations with the required characteristics.

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Response Surface Methodology for an Improved Nanoemulsion of Ivacaftor & Its Optimisation for Solubility and Stability

Cited by 2 publications

References 37 publications

Preparation, Characterization, and Sub-Chronic Toxicity of Carvacrol-Self-Nano-Emulsifying Drug Delivery System Towards Healthy Sprague Dawley Rats

Preparation, Characterization, and Sub-Chronic Toxicity of Carvacrol-Self-Nano-Emulsifying Drug Delivery System Towards Healthy Sprague Dawley Rats

Dissolution Rate Enhancement of Dolutegravir Sodium Through Nanosuspension Technology Using 3 2 Factorial Design

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