Response surface methodology optimised solvothermal system enables an efficient extraction of echinacoside and oleuropein from <scp><i>Syringa pubescens</i></scp> Turcz

Wu, You; Chu, Yindi; Yang, Qinyu; Li, Mengjia; Yu, Miao; Deng, Ruixue; Liu, Kun; Wang, Xinsheng; Fan, Enguo

doi:10.1002/pca.3049

Cited by 9 publications

(2 citation statements)

References 27 publications

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“…The SPF extract possessed strong antioxidant and anti-inflammatory activities [6,7]. The inhibition of AChE has been considered the main approach for the treatment of Alzheimer's disease [31].…”

Section: Enzyme Inhibitory Activitymentioning

confidence: 99%

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Influence of Five Drying Methods on Active Compound Contents and Bioactivities of Fresh Flowers from Syringa pubescens Turcz

Xu,

Zhang,

et al. 2023

Molecules

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The flower of Syringa pubescens Turcz. is used in Chinese folk medicine and also as a flower tea for healthcare. The effects of five drying methods on the active compound contents, the antioxidant abilities, anti-inflammatory properties and enzyme inhibitory activities were evaluated. The plant materials were treated using shade-drying, microwave-drying, sun-drying, infrared-drying and oven-drying. The seven active compounds were simultaneously determined using an HPLC method. Furthermore, the chemical profile was assessed using scanning electron microscopy, ultraviolet spectroscopy and infrared spectroscopy. The antioxidant capacities and protective effects on L02 cells induced with hydrogen peroxide were measured. The anti-inflammatory effects on lipopolysaccharide-induced RAW264.7 cells were investigated. The enzyme inhibitory activities were determined against α-amylase, α-glucosidase cholinesterases and tyrosinase. The results indicated that drying methods had significant influences on the active compound contents and biological properties. Compared with other samples, the OD samples possessed low IC50 values with 0.118 ± 0.004 mg/mL for DPPH radical, 1.538 ± 0.0972 for hydroxyl radical and 0.886 ± 0.199 mg/mL for superoxide radical, while the SHD samples had stronger reducing power compared with other samples. The SHD samples could be effective against H2O2-induced injury on L02 cells by the promoting of T-AOC, GSH-PX, SOD and CAT activities and the reducing of MDA content compared with other samples. Furthermore, SPF samples, especially the SHD sample, could evidently ameliorate inflammation through the inhibition of IL-6, IL-1β and TNF-α expression. All the studied SPF samples exhibited evidently inhibitory effects on the four enzymes. The IC50 values of inhibitory activity on α-glucosidase and α-amylase from SHD sample were 2.516 ± 0.024 and 0.734 ± 0.034 mg/mL, respectively. SD samples had potential inhibitory effects on cholinesterases and tyrosinase with IC50 values of 3.443 ± 0.060 and 1.732 ± 0.058 mg/mL. In consideration of active compound contents and biological activities, it was recommended that SHD and SD be applied for drying SPF at an industrial scale.

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Section: Enzyme Inhibitory Activitymentioning

confidence: 99%

“…These biological properties are due to the presence of chemical constituents in SPF. The main compounds in SPF are phenylethanoid glycosides and iridoids [1][2][3]6,7].…”

Section: Introductionmentioning

confidence: 99%

Influence of Five Drying Methods on Active Compound Contents and Bioactivities of Fresh Flowers from Syringa pubescens Turcz

Xu,

Zhang,

et al. 2023

Molecules

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Purification of Phenylethanoid Glycosides From Syringa pubescens Turcz. via Macroporous Resins and Comparison of Biological Activity

Zhang,

Wu,

Xiong

et al. 2024

Separation Science Plus

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Syringa pubescens Turcz. has been universally employed to make flower tea for the treatment of cough in the western part of Henan Province. Many researchers have confirmed that the phenylethanoid glycosides from S. pubescens were bioactive compounds. In this study, various macroporous resins have been employed to evaluate the potential of adsorption and desorption for phenylethanoid glycosides. The HPD‐450 resins were appropriate for the purification of phenylethanoid glycosides, and the optimum purification conditions were established. The adsorption properties were well modeled using the pseudo‐second‐order kinetics. Meanwhile, the adsorption isotherm could be better represented by the Langmuir equation, suggesting that the process was an exothermic reaction. Moreover, the purified sample possessed a stronger antioxidant capacity. The inhibitory activity of the crude extract against α‐amylase and α‐glucosidase was stronger than that of purified sample. The findings obtained provided a scientific foundation for further research and high‐value exploration of this plant and a potential technique for scale‐up purification of phenylethanoid glycosides.

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Extraction and utilization of active substances from edible fungi substrate and residue: A review

Qin

Liu

et al. 2023

Food Chemistry

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Response surface methodology optimised solvothermal system enables an efficient extraction of echinacoside and oleuropein from Syringa pubescens Turcz

Cited by 9 publications

References 27 publications

Influence of Five Drying Methods on Active Compound Contents and Bioactivities of Fresh Flowers from Syringa pubescens Turcz

Influence of Five Drying Methods on Active Compound Contents and Bioactivities of Fresh Flowers from Syringa pubescens Turcz

Purification of Phenylethanoid Glycosides From Syringa pubescens Turcz. via Macroporous Resins and Comparison of Biological Activity

Extraction and utilization of active substances from edible fungi substrate and residue: A review

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