2022
DOI: 10.3390/molecules27238620
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Response Surface Modeling and Optimization of the Extraction of Phenolic Antioxidants from Olive Mill Pomace

Abstract: Bioactive compounds from olive mill pomace (OMP) were extracted through a two-step solid-liquid extraction procedure considering four factors at five levels of a central composite rotatable response surface design. The influence of the process variables time of the primary extraction (2.0–4.0 h), solvent-to-sample ratio during the primary extraction (5.0–10.0 mL/g), time of the secondary extraction (1.0–2.0 h), and the solvent-to-sample ratio during the secondary extraction (3.0–5.0 mL/g) were examined. The co… Show more

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Cited by 9 publications
(9 citation statements)
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“…The models' capacity to be repeated and reproduced is tested using the CV. The CV illustrates the relationship between the standard error of the estimate and the mean value of the observed response, demonstrating the model's repeatability (Paulo et al, 2022).…”
Section: Resultsmentioning
confidence: 95%
“…The models' capacity to be repeated and reproduced is tested using the CV. The CV illustrates the relationship between the standard error of the estimate and the mean value of the observed response, demonstrating the model's repeatability (Paulo et al, 2022).…”
Section: Resultsmentioning
confidence: 95%
“…The axial points are additional designs to show if the experimental points are at some distance from the centre point. A complete routable central composite designs are characterized as (1) experimental numbers should be calculated as N = 2 k +2k + cp, where k is for the number of extraction process factors, 2 k is for the number of designed factorial points, 2k the number of axial points at a distance of ±α, and cp for the replicate number of the central point; (2) considering the number of variables the α/axial points should be calculated as α = 2 (k)1/4 ; and (3) factors should be investigated at five levels (-α, -1, 0, +1, +α) [39,50].…”
Section: Central Composite Designmentioning
confidence: 99%
“…Fitted/developed models of RSM coupled with CCD optimizations from experimental studies conducted on the extraction of bioactive compounds from seafood byproducts were selected to see their effect on the response or extraction yields. Individual percentage contributions (PC) of extraction variables from RSM coupling CCRD equations can be calculated using the Equation 7 [50,51,52] Total percentage contributions (TPC) of linear, quadratic and interactive terms of the selected independent variables were calculated using Equations 8-10 for better understanding of the effect of extraction variables on yield/response [53,54].…”
Section: Central Composite Designmentioning
confidence: 99%
“…The normal plot of residuals in Figure 2a shows that the model accurately explained the relationship between drying factors and D e value. However, the Box-Cox transformation, which uses a power function to adjust experimental data for statistical analysis [30], shows that the current lambda (1) was not in the confidence interval of 95% (−0.99 ≤ λ ≤ 0.19). In this case, an inverse square transformation (lambda = −0.5) was recommended.…”
Section: Influences Of Drying Factors On Drying Efficiency and Energy...mentioning
confidence: 99%