Response Surface Modeling and Optimization of Accelerated Solvent Extraction of Four Lignans from Fructus Schisandrae

Zhao, Lichun; He, Ying; Deng, Xin; Yang, Gengliang; Li, Wei; Liang, Jian; Tang, Qianli

doi:10.3390/molecules17043618

Cited by 49 publications

(29 citation statements)

References 27 publications

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“…It has been reported that RSM can be used to optimize complex processes used to extract compounds from plants. [222324252627] To our knowledge, there are no reports on the use of RSM to optimize extraction conditions for quercetin, rutin, and kaempferol in buckwheat. In this study, we have focused on establishing a rapid and convenient method for extracting and quantifying three of the flavonoids (quercetin, rutin, and kaempferol) present in F. tataricum .…”

Section: Introductionmentioning

confidence: 99%

Response surface modeling and optimization of ultrasound-assisted extraction of three flavonoids from tartary buckwheat (Fagopyrum tataricum)

et al. 2013

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Background:Buckwheat (Fagopyrum spp., Polygonaceae) is a widely planted food crop. Flavonoids, including quercetin, rutin, and kaempferol, are the main bioactive components in tartary buckwheat (Fagopyrum tataricum (L.) Gaertn). From the nutriological and pharmacological perspectives, flavonoids have great value in controlling blood glucose and blood pressure levels, and they also have antioxidant properties.Objective:To optimize the conditions for extraction of quercetin, rutin, and kaempferol from F. tataricum.Materials and Methods:A combination of ultrasound-assisted extraction (UAE) and response surface methodology (RSM) was used for flavonoid extraction and yield assessment. The RSM was based on a three-level, three-variable Box-Behnken design.Results:Flavonoids were optimally extracted from F. tataricum by using 72% methanol, at 60°C, for 21 minutes. Under these conditions, the obtained extraction yield of the total flavonoids was 3.94%.Conclusion:The results indicated that the UAE method was effective for extraction of flavonoids from tartary buckwheat.

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Section: Introductionmentioning

confidence: 99%

Response surface modeling and optimization of ultrasound-assisted extraction of three flavonoids from tartary buckwheat (Fagopyrum tataricum)

et al. 2013

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Section: Resultsmentioning

confidence: 99%

“…The significance or insignificance of interactions between independent variables corresponds to the contour plot profile. A significant interaction between the independent variables is shown by an elliptical contour plot profile (Zhao et al, 2012). Hence, the highest astaxanthin yield was observed approximately 82 μg/g when the pressure was fixed to approximately 225 MPa and the amount of solvents was increased to 6 ml.…”

Section: Graphical Analysis For Yield Optimizationmentioning

confidence: 92%

Optimization of high‐pressure processing in extraction of astaxanthin from Penaeus monodon carapace using response surface methodology

Irna

Jaswir

Othman

et al. 2018

J Food Process Engineering

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Penaeus monodon is a species of shrimp with astaxanthin content that prevents various diseases and enhances immune system. High‐pressure processing (HPP) is capable of achieving higher extraction astaxanthin yield within short processing time. The aim of this research was to optimize the extraction condition of astaxanthin from P. monodon using HPP using response surface methodology (RSM). The investigation was carried out using variables: pressure (150–250 MPa), holding time (10–20 min), and amount of acetone‐methanol mixture, 7:3, vol/vol (3–7 ml). The optimum condition was achieved at the pressure of 238.54 MPa, 16.29 min of holding time, and 6.59 ml of solvent mixture. The optimum yield of astaxanthin was 95.17 μg/gdw. The R2 value was 0.9836 and the adjusted‐R2 value was 0.9688. These values indicate that the application of RSM to optimize the yield of astaxanthin with HPP has a significant impact in enhancing the yield of astaxanthin.

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“…Nowadays, some effective methods, i.e. microwave‐assisted extraction, accelerated solvent extraction (ASE), supercritical fluid extraction, were frequently used for the extraction of target compounds from various matrices . Among them, ASE was used as an alternative fast extraction method , which utilized organic solvents at high pressures and temperatures above the boiling point as extraction solvent.…”

Section: Introductionmentioning

confidence: 99%

A consecutive preparation method based upon accelerated solvent extraction and high-speed counter-current chromatography for isolation of aesculin from Cortex fraxinus

et al. 2012

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A consecutive preparation method based upon accelerated solvent extraction (ASE) coupled with high-speed counter-current chromatography (HSCCC) was presented and aesculin was obtained from Cortex fraxinus. The extraction condition of ASE was optimized with response surface methodology; some significant parameters such as the solvent system and its stability, the amount of loading sample in HSCCC were also investigated. The original sample was first extracted with methanol at 105°C and 104 bar for 7 min using ASE, then the extracts were consecutively introduced into the HSCCC system and separated and purified with the same ethyl acetate/n-butanol/water (7:3:10, v/v/v) solvent system for five times without further exchange and equilibrium. About 3.1 ± 0.2 mg/g in each time and total of 15.4 mg/g aesculin with purity over 95% was isolated from Cortex fraxinus. The results demonstrated that the consecutive preparation method was time and solvent saving and high throughput, it was suitable for isolation of aesculin from Cortex fraxinus, and also has good potential on the separation and purification of effective compounds from natural product.

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Response Surface Modeling and Optimization of Accelerated Solvent Extraction of Four Lignans from Fructus Schisandrae

Cited by 49 publications

References 27 publications

Response surface modeling and optimization of ultrasound-assisted extraction of three flavonoids from tartary buckwheat (Fagopyrum tataricum)

Response surface modeling and optimization of ultrasound-assisted extraction of three flavonoids from tartary buckwheat (Fagopyrum tataricum)

Optimization of high‐pressure processing in extraction of astaxanthin from Penaeus monodon carapace using response surface methodology

A consecutive preparation method based upon accelerated solvent extraction and high-speed counter-current chromatography for isolation of aesculin from Cortex fraxinus

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