Streamflow prediction is vital to control the effects of floods and mitigation. Physical prediction model often provides satisfactory results, but these models require massive computational work and hydrogeomorphological variables to develop a prediction system. At the same time, data-driven prediction models are quick to apply, easy to handle, and reliable. This study investigates a new hybrid model, the wavelet bootstrap quadratic response surface, for accurate streamflow prediction. Wavelet analysis is a well-known time-frequency joint analysis technique applied in various fields like biological signals, vibration signals, and hydrological signals. The wavelet analysis is used to denoise the time series data. Bootstrap is a nonparametric method for removing uncertainty that uses an intensive resampling methodology with replacement. The authors analyzed the results of the studied models with different statistical metrics, and it has been observed that the wavelet bootstrap quadratic response surface model provides the most efficient results.