Response to Bazzigaluppi et al.: capillary whole-blood measurement of islet autoantibodies.

Costa, Arthur Brício Silva; Conget, Ignacio; Casamitjana, Roser

doi:10.2337/diacare.23.6.874b

Diabetes Care

2000

DOI: 10.2337/diacare.23.6.874b

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Response to Bazzigaluppi et al.: capillary whole-blood measurement of islet autoantibodies.

Arthur Brício Silva Costa¹,

Ignacio Conget²,

Roser Casamitjana³

Abstract: Sane , Saito H: Endogenous glucose production and glucose effectiveness in type 2 diabetic subjects derived from stablelabeled minimal model approach.

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“…1 Collecting capillary blood samples offers a potential alternative [2][3][4] and could also give additional flexibility for staff. If samples can ultimately be collected at home, it could mean that families recruited for screening would not need to come to a clinic, hospital, or laboratory for venipuncture and could therefore enhance recruitment.…”

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confidence: 99%

Use of Dried Capillary Blood Sampling for Islet Autoantibody Screening in Relatives: A Feasibility Study

BingleyPolly

RafkinLisa

MathesonDella

et al. 2015

Diabetes Technology & Therapeutics

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Background: Islet autoantibody testing provides the basis for assessment of risk of progression to type 1 diabetes. We set out to determine the feasibility and acceptability of dried capillary blood spot-based screening to identify islet autoantibody-positive relatives potentially eligible for inclusion in prevention trials. Materials and Methods: Dried blood spot (DBS) and venous samples were collected from 229 relatives participating in the TrialNet Pathway to Prevention Study. Both samples were tested for glutamic acid decarboxylase, islet antigen 2, and zinc transporter 8 autoantibodies, and venous samples were additionally tested for insulin autoantibodies and islet cell antibodies. We defined multiple autoantibody positive as two or more autoantibodies in venous serum and DBS screen positive if one or more autoantibodies were detected. Participant questionnaires compared the sample collection methods. Results: Of 44 relatives who were multiple autoantibody positive in venous samples, 42 (95.5%) were DBS screen positive, and DBS accurately detected 145 of 147 autoantibody-negative relatives (98.6%). Capillary blood sampling was perceived as more painful than venous blood draw, but 60% of participants would prefer initial screening using home fingerstick with clinic visits only required if autoantibodies were found. Conclusions: Capillary blood sampling could facilitate screening for type 1 diabetes prevention studies.

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mentioning

confidence: 99%

Use of Dried Capillary Blood Sampling for Islet Autoantibody Screening in Relatives: A Feasibility Study

BingleyPolly

RafkinLisa

MathesonDella

et al. 2015

Diabetes Technology & Therapeutics

View full text Add to dashboard Cite

show abstract

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Response to Bazzigaluppi et al.: capillary whole-blood measurement of islet autoantibodies.

Abstract: Sane , Saito H: Endogenous glucose production and glucose effectiveness in type 2 diabetic subjects derived from stablelabeled minimal model approach.

Cited by 1 publication

References 0 publications

Use of Dried Capillary Blood Sampling for Islet Autoantibody Screening in Relatives: A Feasibility Study

Use of Dried Capillary Blood Sampling for Islet Autoantibody Screening in Relatives: A Feasibility Study

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