Response to Collinson et al. Comment

5613398 a Drug Repositioning Project for Β-Thalassemia: Sirolimus and Cinchona Alkaloids

“…Inhibition of NMDARs with Memantine, a drug used in Alzheimer's disease, emerges as a novel treatment in SCD. Memantine administration in 6 SCD adults demonstrated safety (Hegemann I. et al, 2020); and suggested a reduction of RBCs irreversible sickling (Makhro A, et al, 2020). Aims: This phase IIa-IIb open-label, single-center trial aims to study the safety, tolerability, and efficacy of Memantine in adults and teenagers with SCD (NCT03247218).…”