Response to drugs in schizophrenia: the influence of family history, obstetric complications and ventricular enlargement

Nimgaonkar, V.L.; Wessely, Simon; Tune, L.E.; Murray, Robin M.

doi:10.1017/s0033291700008266

Cited by 33 publications

(9 citation statements)

References 45 publications

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“…Patient in that study had an average length of illness between 15 and 20 years and the measure of Norman et al The Journal of Nervous and Mental Disease • Volume 195, Number 10, October 2007 treatment response did not provide a clear separation of positive and negative symptoms. Several other past studies that have examined treatment outcome as a function of family history do not focus on first-episode patients and/or do allow a separate assessment of positive and negative symptoms (e.g., Chanpattana and Chakrabhand, 2001;Feldman et al, 2001;Ganev 2000;Nimgaonkar et al, 1988;Silverman et al, 1987;Verdoux et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…Because these potential correlates of family history can in their own right be related to premorbid characteristics or course of illness (Nimgaonkar et al, 1988;Riecher-Rössler and Häfner, 2000), it is advisable to control for them if we are to clearly examine the impact of family history per se. In the current article we report the results of a comparison of family history positive and negative cases of schizophrenia spectrum disorder in a first-episode program using a case comparison method matching for sex and age of onset.…”

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confidence: 99%

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The Significance of Family History in First-Episode Schizophrenia Spectrum Disorder

Norman

Manchanda²,

Malla³

et al. 2007

Journal of Nervous &Amp; Mental Disease

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There have been inconsistent findings regarding the significance of family history of schizophrenia spectrum disorders in relation to presentation and course of illness. There has been little research relevant to this issue from first-episode patients. We examined the differences in premorbid adjustment, symptoms, and intellectual functioning between 28 first-episode schizophrenia spectrum patients with a history of such illness in first degree relatives and 28 matched patients without such a family history. The results indicate that whereas the 2 groups did not differ in presenting symptoms, those with a positive family history showed poorer intellectual functioning and less reduction in symptoms at 2 and 3 year follow-up and greater likelihood of abnormal electroencephalogram findings. The findings provide evidence that presence of a positive family history in first-episode patients is associated with a more pernicious form of illness.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The Significance of Family History in First-Episode Schizophrenia Spectrum Disorder

Norman

Manchanda²,

Malla³

et al. 2007

Journal of Nervous &Amp; Mental Disease

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“…Early onset has been associated with poor response to neuroleptic treatment [15][16][17][18] and worse long-term outcome. 19,20 Häfner et al 1989 21 found that, specifically for men, symptom severity decreased with later onset.…”

Section: Figurementioning

confidence: 99%

Dopa decarboxylase genotypes may influence age at onset of schizophrenia

Børglum¹,

Hampson

Kjeldsen³

et al. 2001

Mol Psychiatry

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Several lines of evidence implicate dopa decarboxylase (DDC) with schizophrenia. By analysis of two putative functional DDC variants in 173 schizophrenic patients and 204 controls we tested the hypotheses that DDC is involved in: (1) predisposition to schizophrenia; and (2) modulation of age at disease onset. No association was observed with schizophrenia as a whole, whereas an association between DDC genotypes and age at disease onset was suggested in males (P = 0.03). This association was most pronounced in relation to genotypes of haplotypes comprising both variants, suggesting an additive model where one variant mediates early and the other late onset. Accordingly, the haplotypebased genotypes could be assigned into three groups by their possible relative effect on age at onset: an 'early', 'neutral' and 'late' group. Dividing the male schizophrenics into four groups with increasing age at onset, the 'early' genotypes were seen to decrease in frequency from 51.5% to 16.7% while the 'late' genotypes increased from 12.1% to 33.3% (P = 0.02). The difference in mean age at onset between male patients with 'early' genotypes vs patients with 'late' genotypes was close to 5 years (95% CI: 0.7-8.8). Thus, DDC may possibly act as a modulator of age at onset in male schizophrenics. Molecular Psychiatry (2001) 6, 712-717.

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“…It now seems that individuals who present with negative symptoms may not only have positive symptoms at the same time, but they may relapse with predominantly positive symptoms (Kay et al, 1986). Positive symptoms do appear to respond better than negative symptoms to antipsychotics, but there has been little empirical evidence of a differential response between patients with and without CT abnormalities (Nimgaonkar et al, 1988). Nevertheless, there appears to be a relationship between negative symptoms, intellectual impairment and neurological signs, and between each of these and enlarged ventricles (Crow, 1985).…”

Section: Determining the Validity Of Different Definitionsmentioning

confidence: 99%