Response to: Glycemic control and COVID-19 outcomes: the missing metabolic players

Zhan, Kegang; Zhang, Xiao‐Hua; Wang, Bin; Jiang, Zheng; Fang, Xiaoyu; Yang, Sha; Jia, Hong; Li, Li; Cao, Guoqiang; Zhang, Kejun; Ma, Xiangyu

doi:10.1093/qjmed/hcac044

Cited by 1 publication

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 11 , 12 Interest in the potential effect of antidiabetic therapy on clinical outcomes of COVID-19 patients with T2D has increased. 11 , 13 , 14 …”

Section: Introductionmentioning

confidence: 99%

“…11,12 Interest in the potential effect of antidiabetic therapy on clinical outcomes of COVID-19 patients with T2D has increased. 11,13,14 There are a wide variety of antidiabetic drugs with different mechanisms, however, no study has yet systematically evaluated the effect of antidiabetic therapy on clinical outcomes of COVID-19 patients with T2D. At present, these antidiabetic drugs, including metformin, insulin, thiazolidinediones (TZDs), dipeptidyl-peptidase 4 inhibitors (DPP-4i), sulfonylureas (SUs), sodium-glucose cotransporter-2 inhibitors (SGLT-2i), glucagon-like peptide-1 receptor agonists (GLP-1ra), and α-glycosidase inhibitors (AGIs), are being used to control blood glucose level and improve clinical outcomes of COVID-19 patients with T2D.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Antidiabetic Therapy on Clinical Outcomes of COVID-19 Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis

Zhan

Weng

Li³

et al. 2022

Ann Pharmacother

Self Cite

View full text Add to dashboard Cite

Background: No study has yet systematically evaluated the effect of antidiabetic therapy on clinical outcomes of COVID-19 patients with type 2 diabetes (T2D). Objective: We aimed to evaluate the effect of different antidiabetic therapy on clinical outcomes of COVID-19 patients with T2D. Methods: We comprehensively retrieved the published research which examined the effect of antidiabetic therapy on clinical outcomes of COVID-19 patients with T2D. The odds ratio (OR) and its 95% confidence interval (95% CI) for clinical outcomes were calculated using the random-effects model, and meta-regression was adopted to evaluate the potential sources of heterogeneity between studies. Results: A total of 54 studies were included in this study. We found that the use of metformin (OR = 0.66, 95% CI: 0.58-0.75), SGLT-2i (OR = 0.80, 95% CI: 0.73-0.88), and GLP-1ra (OR = 0.83, 95% CI: 0.70-0.98) were significantly associated with lower mortality risk in COVID-19 patients with T2D, while insulin use might unexpectedly increase the ICU admission rate (OR = 2.32, 95% CI: 1.34-4.01) and risk of death (OR = 1.52, 95% CI: 1.32-1.75). No statistically significant associations were identified for DPP-4i, SUs, AGIs, and TZDs. Conclusion and Relevance: We demonstrated that the usage of metformin, SGLT-2i, and GLP-1ra could significantly decrease mortality in COVID-19 patients with T2D. The heterogeneity across the studies, baseline characteristics of the included patients, shortage of dosage and the duration of antidiabetic drugs and autonomy of drug selection might limit the objectivity and accuracy of results. Further adequately powered and high-quality randomized controlled trials are warranted for conclusive findings.

show abstract

“… 11 , 12 Interest in the potential effect of antidiabetic therapy on clinical outcomes of COVID-19 patients with T2D has increased. 11 , 13 , 14 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Antidiabetic Therapy on Clinical Outcomes of COVID-19 Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis

Zhan

Weng

Li³

et al. 2022

Ann Pharmacother

Self Cite

View full text Add to dashboard Cite

show abstract

Response to: Glycemic control and COVID-19 outcomes: the missing metabolic players

Cited by 1 publication

References 11 publications

Effect of Antidiabetic Therapy on Clinical Outcomes of COVID-19 Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis

Effect of Antidiabetic Therapy on Clinical Outcomes of COVID-19 Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About