2021
DOI: 10.3389/fimmu.2021.659625
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Response to Hypomethylating Agents in Myelodysplastic Syndrome Is Associated With Emergence of Novel TCR Clonotypes

Abstract: Aberrant T-cell function is implicated in the pathogenesis of myelodysplastic syndrome (MDS). Monitoring the T-cell receptor (TCR) repertoire can provide insights into T-cell adaptive immunity. Previous studies found skewed TCR repertoires in MDS compared to healthy patients; however these studies that leverage mRNA-based spectratyping have limitations. Furthermore, evaluating the TCR repertoire in context of hypomethylating agents (HMAs) treatment can provide insights into the dynamics of T-cell mediated resp… Show more

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Cited by 9 publications
(2 citation statements)
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References 31 publications
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“…According to the TCR β‐seq database, we utilized the Morisita Overlap Index (MOI) to quantitatively assess the overlapping clonotypes between each two samples by considering the composition and abundance of T‐cell rearrangements (Figure 2D–F ). 22 TCR clonotypes showed a higher degree of overlap between patients in BCLC_C stage than in BCLC_A and BCLC_B stages in tumors and PBMCs, but with no statistical significance.…”
Section: Resultsmentioning
confidence: 83%
“…According to the TCR β‐seq database, we utilized the Morisita Overlap Index (MOI) to quantitatively assess the overlapping clonotypes between each two samples by considering the composition and abundance of T‐cell rearrangements (Figure 2D–F ). 22 TCR clonotypes showed a higher degree of overlap between patients in BCLC_C stage than in BCLC_A and BCLC_B stages in tumors and PBMCs, but with no statistical significance.…”
Section: Resultsmentioning
confidence: 83%
“…However, clonotype contraction was observed in NR following HMA treatment. The distinct clonotype dynamics are likely attributed to HMA therapy, though the direct effects of HMA on T cells remains unclear ( 43 ). Thus, there is potential for leveraging T cells as a therapeutic strategy in combating hematologic malignancies, including AML, but our current understanding does not afford for us to effectively do so.…”
Section: Discussionmentioning
confidence: 99%